TRIM11 Inhibitors
Chemical inhibitors of TRIM11 can interfere with the protein's function by affecting different aspects of the ubiquitin-proteasome system (UPS), a cellular pathway responsible for degrading unnecessary or damaged proteins. MG-132, a proteasome inhibitor, can lead to the accumulation of ubiquitinated proteins. This can overload the UPS, where TRIM11 operates, leading to its functional inhibition as proteins that TRIM11 would typically mark for degradation are not broken down. Similarly, Lactacystin, Clasto-Lactacystin β-lactone, and Epoxomicin serve as proteasome inhibitors, which can result in the functional inhibition of TRIM11 by preventing the turnover of ubiquitinated proteins, thus interfering with TRIM11's role in the degradation process.
Other chemicals target different components of the ubiquitination machinery. For instance, MLN4924 inhibits the NEDD8-activating enzyme, which is essential for the activity of cullin-RING ligases (CRLs). Given that TRIM11 is a RING-type E3 ubiquitin ligase, the inhibition of CRLs by MLN4924 can indirectly lead to the functional inhibition of TRIM11 by disrupting ubiquitin ligase activity. PYR-41, an inhibitor of the ubiquitin-activating enzyme E1, can prevent the initial step of ubiquitination, thereby inhibiting the enzyme cascade that would usually lead to TRIM11-mediated protein ubiquitination. Bortezomib, Carfilzomib, IXAZOMIB, Oprozomib, and Marizomib, all proteasome inhibitors, can similarly lead to the functional inhibition of TRIM11. They achieve this by inhibiting the 26S proteasome or the 20S core particle, which are responsible for the degradation of polyubiquitinated substrates. The inhibition of these proteasomal components prevents the breakdown of proteins tagged by TRIM11, which can interfere with TRIM11's role in regulating protein levels within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
This proteasome inhibitor can lead to the accumulation of ubiquitinated proteins, thus potentially overloading the ubiquitin-proteasome system (UPS) which TRIM11 is known to be a part of, leading to functional inhibition of TRIM11's role in protein degradation. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin inhibits the proteasome, which could lead to the functional inhibition of TRIM11 by preventing the degradation of proteins that TRIM11 would typically ubiquitinate, hence blocking TRIM11's role in the UPS. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
By inhibiting the 26S proteasome, Bortezomib can indirectly inhibit TRIM11 by disrupting the degradation pathway for ubiquitinated proteins, of which TRIM11 is a component. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
Carfilzomib, another proteasome inhibitor, may indirectly inhibit TRIM11 by halting the degradation of polyubiquitinated substrates, which could include those tagged by TRIM11 for degradation. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
This inhibitor of the NEDD8-activating enzyme can inhibit cullin-RING ligases (CRLs). Since TRIM11 is a RING-type E3 ubiquitin ligase, inhibition of CRLs could indirectly lead to the functional inhibition of TRIM11 by disrupting ubiquitin ligase activity related to its pathway. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 is an inhibitor of ubiquitin activating enzyme E1, which indirectly inhibits TRIM11 by preventing the initial step of ubiquitination, thereby functionally inhibiting the ubiquitin ligase activity of TRIM11. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
As a selective proteasome inhibitor, Epoxomicin can inhibit the degradation of polyubiquitinated proteins, potentially leading to functional inhibition of TRIM11 by stalling the protein degradation process that TRIM11 is part of. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
IXAZOMIB inhibits the 20S proteasome, which could result in the functional inhibition of TRIM11 by preventing the breakdown of ubiquitinated proteins, thus potentially impairing TRIM11's role in the UPS. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
Oprozomib, another proteasome inhibitor, can lead to the functional inhibition of TRIM11 by blocking the proteolytic function of the proteasome, thus indirectly affecting the ubiquitination process performed by TRIM11. | ||||||