Trav8d-1 Inhibitors
Trav8d-1 inhibitors are a class of chemical compounds that specifically target and inhibit the Trav8d-1 gene segment, which encodes a portion of the variable region in the T-cell receptor (TCR) alpha chain. This region plays an essential role in recognizing antigens presented by major histocompatibility complex (MHC) molecules, contributing to the adaptive immune system's ability to detect and respond to diverse pathogens. By inhibiting Trav8d-1, these compounds disrupt the formation or function of specific TCRs, which can affect antigen recognition and downstream immune responses.
Chemically, Trav8d-1 inhibitors are designed to interact with the molecular mechanisms that govern the expression or integration of the Trav8d-1 gene segment into the TCR complex. This may involve binding to key regions of the gene or its regulatory elements, blocking its transcription or translation, or inhibiting the formation of a functional TCR alpha chain. Researchers are interested in these inhibitors to better understand the precise role of specific TCR variable regions like Trav8d-1 in immune recognition and how they contribute to the immune system's ability to adapt to and target a wide range of antigens. By studying Trav8d-1 inhibitors, scientists gain insights into the broader mechanisms of T-cell diversity and the regulation of antigen-specific immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine A inhibits T cell receptor alpha variable 8D-1 expression by suppressing calcineurin activity, a key signaling molecule in T cell activation and differentiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits T cell receptor alpha variable 8D-1 expression by targeting mTOR signaling pathway, which regulates T cell proliferation and differentiation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits T cell receptor alpha variable 8D-1 expression by interfering with the synthesis of nucleotides, leading to impaired T cell proliferation and activation. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Tacrolimus inhibits T cell receptor alpha variable 8D-1 expression by binding to FKBP12 and blocking calcineurin activity, resulting in decreased T cell activation and cytokine production. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
Fingolimod inhibits T cell receptor alpha variable 8D-1 expression by sequestering lymphocytes in lymph nodes, reducing the number of circulating T cells available for activation. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine inhibits T cell receptor alpha variable 8D-1 expression by interfering with purine synthesis, leading to reduced T cell proliferation and cytokine production. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
Everolimus inhibits T cell receptor alpha variable 8D-1 expression by targeting mTOR signaling pathway, resulting in suppression of T cell activation and proliferation. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits T cell receptor alpha variable 8D-1 expression by blocking inosine monophosphate dehydrogenase, an enzyme essential for de novo purine synthesis. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
Leflunomide inhibits T cell receptor alpha variable 8D-1 expression by inhibiting dihydroorotate dehydrogenase, a key enzyme in pyrimidine synthesis, leading to impaired T cell function. | ||||||