Topo Inhibitors
Items 11 to 19 of 19 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitoxantrone Dihydrochloride | 70476-82-3 | sc-203136 sc-203136A sc-203136B sc-203136C | 10 mg 50 mg 100 mg 1 g | $42.00 $68.00 $126.00 $785.00 | 6 | |
Mitoxantrone Dihydrochloride acts as a topoisomerase inhibitor by forming stable complexes with the enzyme-DNA interface, primarily through π-π stacking interactions and electrostatic attractions. Its distinct anthraquinone structure allows for effective intercalation within the DNA helix, causing significant alterations in DNA supercoiling. This disruption impacts the enzyme's activity, resulting in an accumulation of DNA strand breaks and influencing cellular processes related to DNA topology. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine functions as a topoisomerase inhibitor by engaging in unique hydrogen bonding and hydrophobic interactions with the enzyme-DNA complex. Its planar structure facilitates intercalation between DNA base pairs, leading to torsional strain and altered superhelical density. This interaction disrupts the enzyme's catalytic cycle, promoting the stabilization of transient DNA breaks and influencing the dynamics of DNA replication and repair mechanisms. | ||||||
Moxifloxacin Hydrochloride | 186826-86-8 | sc-205758 sc-205758A | 100 mg 500 mg | $122.00 $452.00 | 18 | |
Moxifloxacin Hydrochloride acts as a topoisomerase inhibitor through its ability to form specific π-π stacking interactions with DNA, enhancing its binding affinity to the enzyme-DNA complex. Its unique bicyclic structure allows for effective intercalation, inducing conformational changes that hinder the enzyme's activity. This disruption alters the topological state of DNA, impacting the overall dynamics of DNA topology and influencing the stability of the double helix during replication. | ||||||
(S)-10-Hydroxycamptothecin | 19685-09-7 | sc-205614 sc-205614A | 25 mg 100 mg | $200.00 $450.00 | 3 | |
(S)-10-Hydroxycamptothecin acts as a topoisomerase inhibitor by inducing a conformational change in the enzyme-DNA complex, leading to the stabilization of the cleaved DNA strand. Its unique stereochemistry allows for specific interactions with the enzyme's active site, enhancing binding affinity. The compound exhibits a distinctive kinetic profile, with a prolonged residence time on the enzyme, which effectively disrupts DNA replication and transcription processes. | ||||||
SN-38-d3 | 718612-49-8 | sc-208392 sc-208392B sc-208392A sc-208392C | 1 mg 2.5 mg 5 mg 10 mg | $1030.00 $1693.00 $2968.00 $5722.00 | ||
SN-38-d3 functions as a topoisomerase inhibitor by stabilizing the enzyme-DNA complex through hydrogen bonding and hydrophobic interactions. Its distinct structural features facilitate the formation of a stable ternary complex, effectively preventing the re-ligation of DNA strands. This compound exhibits unique reaction kinetics, characterized by a rapid binding phase followed by a slower dissociation, which enhances its efficacy in modulating DNA topology and influencing cellular processes. | ||||||
Genistein-2′,3′,5′,6′-d4 | 187960-08-3 | sc-280728 | 1 mg | $367.00 | ||
Genistein-2',3',5',6'-d4 functions as a topoisomerase modulator, exhibiting unique isotopic labeling that enhances its interaction with the enzyme-DNA complex. This compound alters the enzyme's conformational dynamics, promoting a stable enzyme-DNA complex that inhibits the relaxation of supercoiled DNA. Its distinct kinetic behavior, characterized by a selective binding mechanism, influences the topological state of DNA, thereby impacting nucleic acid processes. | ||||||
1,4-Naphthoquinone | 130-15-4 | sc-237768 sc-237768A | 100 g 250 g | $35.00 $41.00 | ||
1,4-Naphthoquinone acts as a topoisomerase modulator, engaging in specific π-π stacking interactions with DNA bases that stabilize the enzyme-DNA complex. Its unique redox properties facilitate electron transfer, influencing reaction kinetics and promoting conformational changes in the topoisomerase. This compound's ability to intercalate within the DNA helix alters the topological landscape, affecting supercoiling and overall nucleic acid dynamics. | ||||||
Genistein-2′,6′-d2 | 315204-48-9 | sc-280729 | 1 mg | $300.00 | ||
Genistein-2',6'-d2 functions as a topoisomerase modulator by selectively binding to the enzyme's active site, enhancing its catalytic efficiency. Its deuterated structure influences hydrogen bonding patterns, leading to altered reaction kinetics. The compound exhibits unique hydrophobic interactions with the DNA backbone, promoting stability in the enzyme-DNA complex. Additionally, its ability to disrupt local DNA conformations can modulate supercoiling, impacting overall genomic architecture. | ||||||
Temafloxacin Hydrochloride | 105784-61-0 | sc-475068 | 25 mg | $395.00 | ||
Temafloxacin Hydrochloride acts as a topoisomerase modulator by engaging in specific electrostatic interactions with the enzyme, which can alter its conformational dynamics. The presence of halide groups enhances its affinity for nucleophilic sites, facilitating unique reaction pathways. Its distinct solubility characteristics allow for effective diffusion through cellular membranes, while its ability to stabilize transient enzyme-DNA complexes can influence DNA topology and supercoiling dynamics. | ||||||