(S)-10-Hydroxycamptothecin (CAS 19685-09-7)

5.0(1)

Alternate Names: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Hydroxycamptothecin

Application: (S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase I

CAS Number: 19685-09-7

Purity: ≥98%

Molecular Weight: 364.35

Molecular Formula: C₂₀H₁₆N₂O₅

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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(S)-10-Hydroxycamptothecin: sc-205614...

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(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. (S)-10-Hydroxycamptothecin is an inhibitor of Topo I.

References

1. Hertzberg, R.P., et al. 1989. Biochemistry. 28: 4629-4638. PMID: 2548584
2. Cotter, T.G., et al. 1992. Anticancer Res. 12: 773-779. PMID: 1622137

Physical State :

Solid

Solubility :

Soluble in DMSO (5 mg/ml), DMF, and methanol.

Storage :

Store at -20° C

Melting Point :

268-270° C

Boiling Point :

820.71° C at 760 mmHg (Predicted)

Density :

1.61 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.78 (Predicted)

IC50 :

A2780: IC₅₀ = 4 nM (human); HepG2: IC₅₀ = 5.4 nM (human); MDA-231: IC₅₀ = 7.27 nM; HT-29: IC₅₀ = 8.8 nM (human); BT-20: IC₅₀ = 34.3 nM

pK Values :

pK_a: 8.93 (Predicted), pK_b: 4.97 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

RTECS :

UQ0491700

PubChem CID :

97226

MDL Number :

MFCD00189425

SMILES :

CC[[email protected]@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(C=CC(O)=C4)N=C13)C2=O

Download SDS (MSDS)

Certificate of Analysis

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(S)-10-Hydroxycamptothecin (CAS 19685-09-7) Product Citations

See how others have used (S)-10-Hydroxycamptothecin (CAS 19685-09-7). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26463633 Cheng, Y. et al. 2015. Biomed. Pharmacother. 75: 67-74.

PMID: # 24681041 Exp. Eye Res. 43-55.

Citations 1 to 3 of 3 total

Is this synthisized chemically? And Is this a FDA proved drug?

Asked by: two2igm05

Thank you for your question. This is synthesized chemically and it not a FDA approved or proven drug. Please contact Technical Service if you have further questions concerning this product.

Answered by: Tech Service 9

Date published: 2017-01-16

What is the appearance of the compound?

Asked by: two2igm05

Thank you for your question. The chemical, sc-205614, is provided as a light yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.

Answered by: Tech Service 8

Date published: 2017-01-11

Rated 5 out of 5 by MS from Fei Fei, B. et al. (PubMed 23721525) reported that (S)-10-Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression. -SCBT Publication Review

Date published: 2015-02-27

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