(S)-10-Hydroxycamptothecin CAS: 19685-09-7
MF: C20H16N2O5
MW: 364.35
A camptothecin derivative that inhibits DNA topoisomerase I.

(S)-10-Hydroxycamptothecin (CAS 19685-09-7)

(S)-10-Hydroxycamptothecin | CAS 19685-09-7 is rated 5.0 out of 5 by 1.
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Alternate Names: (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Hydroxycamptothecin
Application: (S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase I
CAS Number: 19685-09-7
Purity: ≥98%
Molecular Weight: 364.35
Molecular Formula: C20H16N2O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. (S)-10-Hydroxycamptothecin is an inhibitor of Topo I.


References

1. Hertzberg, R.P., et al. 1989. Biochemistry. 28: 4629-4638. PMID: 2548584
2. Cotter, T.G., et al. 1992. Anticancer Res. 12: 773-779. PMID: 1622137

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), DMF, and methanol.
Storage :
Store at -20° C
Melting Point :
268-270° C
Boiling Point :
820.71° C at 760 mmHg (Predicted)
Density :
1.61 g/cm3 (Predicted)
Refractive Index :
n20D 1.78 (Predicted)
IC50 :
A2780: IC50 = 4 nM (human); HepG2: IC50 = 5.4 nM (human); MDA-231: IC50 = 7.27 nM; HT-29: IC50 = 8.8 nM (human); BT-20: IC50 = 34.3 nM
pK Values :
pKa: 8.93 (Predicted), pKb: 4.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UQ0491700
PubChem CID :
MDL Number :
MFCD00189425
SMILES :
CC[[email protected]@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(C=CC(O)=C4)N=C13)C2=O

Download SDS (MSDS)

Certificate of Analysis

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(S)-10-Hydroxycamptothecin (CAS 19685-09-7)  Product Citations

See how others have used (S)-10-Hydroxycamptothecin (CAS 19685-09-7). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30690843  Yao, Z.|Zheng, W.|Zhang, X.|Xiong, H.|Qian, Y.|Fan, C.| et al. 2019. IUBMB Life. 71: 653-662.

PMID: # 26463633  Cheng, Y. et al. 2015. Biomed. Pharmacother. 75: 67-74.

PMID: # 24681041  Exp. Eye Res. 43-55.

Citations 1 to 3 of 3 total

Is this synthisized chemically? And Is this a FDA proved drug?

Asked by: two2igm05
Thank you for your question. This is synthesized chemically and it not a FDA approved or proven drug. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-16

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The chemical, sc-205614, is provided as a light yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-11
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Rated 5 out of 5 by from Fei Fei, B. et al. (PubMed 23721525) reported that (S)-10-Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression. -SCBT Publication Review
Date published: 2015-02-27
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