(S)-10-Hydroxycamptothecin (CAS 19685-09-7)

(S)-10-Hydroxycamptothecin is an organic compound that is the subject of extensive research in the field of biochemistry, particularly in studies related to DNA replication and cell division. It is known to target the enzyme topoisomerase I, which is essential for DNA unwinding and replication, by stabilizing the complex between the enzyme and DNA, leading to the interruption of the replication process. Research involving (S)-10-Hydroxycamptothecin is focused on understanding its binding affinity and specificity to the topoisomerase I-DNA complex. Additionally, this compound serves as a starting point for the synthesis of various analogs that may exhibit enhanced efficacy or different biochemical properties. The compound′s hydroxyl group is also an important functional moiety that can undergo further chemical modifications, which is useful in structure-activity relationship studies that explore how changes to the molecule affect its biological activity. Researchers are interested in the natural roles of (S)-10-Hydroxycamptothecin and its derivatives in plant defense mechanisms as well.