Molecular structure of Genistein-2′,3′,5′,6′-d4, CAS Number: 187960-08-3
Genistein-2′,3′,5′,6′-d4 (CAS 187960-08-3)
Alternate Names:
5,7-dihydroxy-3-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)chromen-4-one
Application:
Genistein-2′,3′,5′,6′-d4 is a protein kinase inhibitor
CAS Number:
187960-08-3
Purity:
Contains ~14% d3
Molecular Weight:
274.26
Molecular Formula:
C15H6D4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Genistein-2′,3′,5′,6′-d4 exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inihibits tyrosine protein kinase and Topo (DNA topoisomerase)
Genistein-2′,3′,5′,6′-d4 (CAS 187960-08-3) References
Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O′Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: BiochiInhibitor of:
Topo, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Genistein-2′,3′,5′,6′-d4, 1 mg | sc-280728 | 1 mg | $374.00 |