Mitoxantrone Dihydrochloride CAS: 70476-82-3
MF: C22H28N4O6•2HCl
MW: 517.5
Induces DNA damage by intercalating into DNA and inhibiting Topo II.

Mitoxantrone Dihydrochloride (CAS 70476-82-3)

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Alternate Names: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Application: Mitoxantrone Dihydrochloride is induces DNA damage by intercalating into DNA and inhibiting Topo II
CAS Number: 70476-82-3
Purity: ≥99%
Molecular Weight: 517.5
Molecular Formula: C22H28N4O62HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.


References

Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991) Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000) A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002) A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004)

Physical State :
Solid
Solubility :
Soluble in water (89 mg/ml at 25° C), 100% ethanol (slightly), methanol (slightly), and DMSO (89 mg/ml at 25° C). Insoluble in acetone.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.71 (Predicted)
IC50 :
Type II topoisomerase : IC50 = 50 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB5748500
PubChem CID :
51082
Merck Index :
14: 6217
MDL Number :
MFCD00242943
EC Number :
274-619-1
Beilstein Registry :
4835931
SMILES :
C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Mitoxantrone Dihydrochloride (CAS 70476-82-3)  Product Citations

See how others have used Mitoxantrone Dihydrochloride (CAS 70476-82-3). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 31272829  Fang, MY.|Markmiller, S.|Vu, AQ.|Javaherian, A.|Dowdle, WE.|Jolivet, P.|Bushway, PJ.|Castello, NA.|Baral, A.|Chan, MY.|Linsley, JW.|Linsley, D.|Mercola, M.|Finkbeiner, S.|Lecuyer, E.|Lewcock, JW.|Yeo, GW.| et al. 2019. Neuron.

PMID: # 28536462  Wani, A. et al. 2017. Sci Rep. 7: 2274.

PMID: # 25368983  Wallace, RA. et al. 2014. Anal. Chem. 86: 11819-25.

PMID: # 22555380  Wani, A. et al. 2012. Pharm. Res. 29: 2407-18.

Citations 1 to 4 of 4 total
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