Molecular structure of Mitoxantrone Dihydrochloride, CAS Number: 70476-82-3
Mitoxantrone Dihydrochloride (CAS 70476-82-3)
See product citations (6)
Alternate Names:
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Application:
Mitoxantrone Dihydrochloride is induces DNA damage by intercalating into DNA and inhibiting Topo II
CAS Number:
70476-82-3
Purity:
≥98%
Molecular Weight:
517.50
Molecular Formula:
C22H28N4O6•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mitoxantrone Dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone Dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone Dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Mitoxantrone Dihydrochloride (CAS 70476-82-3) References
- Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats. | DiMeco, F., et al. 2002. J Neurosurg. 97: 1173-8. PMID: 12450040
- The genotoxicity of the anti-cancer drug mitoxantrone in somatic and germ cells of Drosophila melanogaster. | Frei, H., et al. 1992. Mutat Res. 279: 21-33. PMID: 1374529
- Doxorubicin and mitoxantrone drug eluting beads for the treatment of experimental peritoneal carcinomatosis in colorectal cancer. | Keese, M., et al. 2009. Int J Cancer. 124: 2701-8. PMID: 19165866
- Superhydrophobic analyte concentration utilizing colloid-pillar array SERS substrates. | Wallace, RA., et al. 2014. Anal Chem. 86: 11819-25. PMID: 25368983
- Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: in vitro and in vivo investigations. | Zafar, S., et al. 2014. Int J Pharm. 477: 454-68. PMID: 25445525
- Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease. | Dixon, M., et al. 2015. Bioorg Med Chem. 23: 1102-11. PMID: 25650313
- Investigation of Cytotoxic Activity of Mitoxantrone at the Individual Cell Level by Using Ionic-Liquid-Tag-Enhanced Mass Spectrometry. | Kucherov, FA., et al. 2017. Anal Chem. 89: 13374-13381. PMID: 29214808
- Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a Commercially Available Small Compound Library With Colistin Against Pseudomonas aeruginosa. | Torres, NS., et al. 2018. Front Microbiol. 9: 2541. PMID: 30410476
- Antiviral activity of mitoxantrone dihydrochloride against human herpes simplex virus mediated by suppression of the viral immediate early genes. | Huang, Q., et al. 2019. BMC Microbiol. 19: 274. PMID: 31812160
- Characterization of the fluorescence of the antitumor agent, mitoxantrone. | Bell, DH. 1988. Biochim Biophys Acta. 949: 132-7. PMID: 3334848
- In silico derived small molecules targeting the finger-finger interaction between the histone lysine methyltransferase NSD1 and Nizp1 repressor. | Berardi, A., et al. 2020. Comput Struct Biotechnol J. 18: 4082-4092. PMID: 33363704
- Slow Release Kinetics of Mitoxantrone from Ordered Mesoporous Carbon Films. | Labiano, A., et al. 2012. Microporous Mesoporous Mater. 160: 143-150. PMID: 34483711
- Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal. | Kumar, P., et al. 2022. RSC Adv. 12: 5648-5655. PMID: 35425590
Inhibitor of:
hCAP-D2, PACSIN1, RUNX1, Topo, and Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mitoxantrone Dihydrochloride, 10 mg | sc-203136 | 10 mg | $42.00 | |||
Mitoxantrone Dihydrochloride, 50 mg | sc-203136A | 50 mg | $68.00 | |||
Mitoxantrone Dihydrochloride, 100 mg | sc-203136B | 100 mg | $126.00 | |||
Mitoxantrone Dihydrochloride, 1 g | sc-203136C | 1 g | $785.00 |