Molecular structure of SN-38-d3, CAS Number: 718612-49-8
SN-38-d3 (CAS 718612-49-8)
Alternate Names:
7-Ethyl-10-hydroxycamptothecin-d3
Application:
SN-38-d3 is A metabolite of Irinotecan, a DNA topoisomerase inhibitor.
CAS Number:
718612-49-8
Molecular Weight:
395.42
Molecular Formula:
C22H17D3N2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SN-38-d3 is a deuterated version of SN-38. SN-38 is a metabolite of Irinotecan, a DNA topoisomerase inhibitor. By incorporating deuterium, researchers can observe how SN-38 behaves in biological systems with greater precision, understanding its absorption, distribution, metabolism, and excretion patterns. This information is for elucidating the pathways through which compounds are processed. Moreover, the use of SN-38-d3 enables the detailed investigation of enzyme interactions and the identification of metabolites, providing a deeper understanding of the molecular mechanisms underlying its activity.
SN-38-d3 (CAS 718612-49-8) References
- Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1. | Wang, L., et al. 2017. Oncotarget. 8: 41572-41581. PMID: 28157715
- Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations. | Aoullay, Z., et al. 2022. Lab Med. 53: 47-52. PMID: 34351422
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Topo.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SN-38-d3, 1 mg | sc-208392 | 1 mg | $1030.00 | |||
SN-38-d3, 2.5 mg | sc-208392B | 2.5 mg | $1727.00 | |||
SN-38-d3, 5 mg | sc-208392A | 5 mg | $3027.00 | |||
SN-38-d3, 10 mg | sc-208392C | 10 mg | $5836.00 |