Tns2 Activators
Tns2 activators are chemical entities that are designed to augment the biological activity of the Tensin2 (Tns2) protein. The Tns2 protein plays a pivotal role in cellular functions related to the actin cytoskeleton, focal adhesions, and signal transduction, with particular importance in the communication between the extracellular matrix and the cell interior. By binding to specific regions of the Tns2 protein, activators can enhance its natural interactions with other proteins and lipids within the cellular milieu. Such interactions are integral to the structural integrity of cells, as well as their ability to respond to external mechanical stimuli. Tns2 activators may operate by stabilizing the protein, promoting its association with other signaling or structural proteins, or by facilitating its localization to particular cellular compartments where it exercises its function. The molecular design of these activators is informed by a deep understanding of the Tns2 protein structure, including its PTB (phosphotyrosine-binding) domain, SH2 (Src Homology 2) domain, and other functional regions that mediate its interactions.
The development of Tns2 activators involves a meticulous approach to molecular design, often incorporating aspects of medicinal chemistry, computational modeling, and structure-activity relationship studies. The objective is to create molecules that can interact precisely with the Tns2 protein, enhancing its activity without disrupting the delicate balance of signaling networks within the cell. Such molecules typically mimic endogenous ligands or modulate the conformation of Tns2 to increase its activity. The specificity of these activators is paramount; they must engage with Tns2 in a manner that potentiates the desired interactions without inducing off-target effects that could perturb other cellular processes. Research into Tns2 activators includes the synthesis of novel compounds followed by rigorous biochemical and biophysical assays to assess their efficacy in modulating Tns2.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can upregulate the expression of various proteins by activating insulin receptor and its downstream signaling pathways, such as the PI3K/AKT pathway, which might lead to the transcription and translation of Tns2. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, can bind to the glucocorticoid receptor, translocate to the nucleus and enhance the transcription of certain proteins. This process could potentially induce the expression of Tns2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can stimulate the expression of various proteins via its anti-inflammatory and antioxidant effects. It modulates the activity of several transcription factors and signaling pathways, which could potentially lead to increased Tns2 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, could potentially enhance Tns2 expression by modulating various gene expression pathways. It has been shown to activate SIRT1, a protein involved in regulating cellular health and gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-estradiol, the primary female sex hormone, binds to the estrogen receptor and can enhance the transcription of certain proteins. This process could potentially increase the expression of Tns2. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays a role in cell growth and differentiation. It can bind to nuclear receptors and induce the transcription of specific genes, potentially including Tns2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin can enhance cAMP levels, activating PKA, which can phosphorylate and activate cAMP response element-binding protein (CREB), a transcription factor that can induce the expression of various proteins, potentially including Tns2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of protein synthesis and cell growth. This inhibition can lead to a compensatory increase in the expression of certain proteins, potentially including Tns2. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its active metabolite calcitriol, can bind to the vitamin D receptor and interact with specific vitamin D response elements (VDREs) on the DNA, leading to the transcription of specific genes, potentially including Tns2. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid, being critical for the synthesis of nucleotides, could potentially upregulate the transcription and translation processes in the cell, leading to the increased expression of a range of proteins, potentially including Tns2. | ||||||