TMEM72 Inhibitors
TMEM72 inhibitors are a class of chemical agents that specifically target and interact with the transmembrane protein 72 (TMEM72). TMEM72 is a protein encoded by the TMEM72 gene and is an integral part of cellular membranes. TMEM72 are known to play critical roles in various cellular processes due to their location within the cell membrane, which serves as a dynamic interface for signal transduction, cellular transport, and intercellular communication. Inhibitors of this protein could potentially influence these fundamental cellular mechanisms by modulating the activity of TMEM72. As the name suggests, TMEM72 inhibitors would bind to this protein, altering its natural function by inhibiting its activity. The inhibitors could be small molecules, peptides, antibodies, or other biologically active compounds that have an affinity for TMEM72 and the capability to modulate its function.
Chemically, TMEM72 inhibitors would be characterized by their ability to selectively engage with the TMEM72 protein. The design and development of such inhibitors require a deep understanding of the protein's structure, the nature of its active sites, and the conformational dynamics that the protein undergoes during its functional cycle. Typically, inhibitors are crafted to fit into specific regions of a target protein in a manner akin to a key fitting into a lock. This specificity is crucial in order to minimize off-target effects and to ensure that the inhibitor's action is as precise as possible. The development of TMEM72 inhibitors would thus involve extensive structure-activity relationship (SAR) studies, where variations in the chemical structure of potential inhibitors are analyzed for their impact on binding efficacy and selectivity. Advanced techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling are often employed to elucidate the interaction between TMEM72 and its inhibitors at the molecular level. These studies help in refining the molecular characteristics of TMEM72 inhibitors, paving the way for the synthesis of compounds with optimal properties for engaging with the target protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that blocks the PI3K/Akt signaling pathway. Since TMEM72 has been implicated in cellular processes that could be regulated by PI3K signaling, LY294002 may lead to a reduction in TMEM72 activity by decreasing downstream Akt signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that interferes with the MAPK/ERK pathway. TMEM72, being associated with cellular membrane processes, could be indirectly influenced by the MAPK/ERK pathway, and inhibition by PD98059 might result in reduced TMEM72 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor. The p38 MAPK pathway is involved in stress responses and could potentially interact with membrane proteins such as TMEM72; inhibition by SB203580 could therefore diminish TMEM72's functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Another PI3K inhibitor similar to LY294002, wortmannin could indirectly decrease TMEM72 activity by impeding PI3K/Akt pathway signaling, which may be necessary for the full functional expression of TMEM72. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that impedes the JNK signaling pathway. Since TMEM72 is a transmembrane protein, it may be involved in pathways modulated by JNK, and its inhibition by SP600125 could lead to decreased TMEM72 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that can suppress the mTORC1 signaling pathway. TMEM72 might be indirectly affected by mTOR activity due to potential crosstalk between mTOR signaling and membrane protein turnover, thus rapamycin could inhibit TMEM72 function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
V-ATPase inhibitor that disrupts lysosomal acidification and autophagy. Due to the involvement of TMEM72 in cellular processes that might be coupled with autophagy, the inhibition of autophagy by bafilomycin A1 could negatively affect TMEM72 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Src family kinase inhibitor. As Src kinases can influence transmembrane signaling, inhibition by PP2 could lead to a decrease in TMEM72 activity by altering signaling pathways in which TMEM72 may play a role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Another MEK inhibitor that blocks the MAPK/ERK signaling. Similar to PD98059, U0126 could indirectly suppress TMEM72 activity through the inhibition of the MAPK/ERK pathway, which may influence the function of TMEM72. | ||||||
NF 449 | 389142-38-5 | sc-203159 | 10 mg | $308.00 | 5 | |
Gs alpha subunit inhibitor. By inhibiting Gs alpha, NF449 could attenuate cAMP/PKA signaling pathways that may interact with TMEM72, leading to decreased TMEM72 activity. | ||||||