TMEM206 Activators
TMEM206 Activators encompass a series of chemical compounds that indirectly influence the activity of TMEM206 through distinct signaling pathways and cellular mechanisms. Compounds like Forskolin and IBMX enhance intracellular levels of cAMP and cGMP, leading to the activation of protein kinase A (PKA), which could phosphorylate and thereby increase the functional activity of TMEM206. Similarly, the calcium channel activators FPL 64176 and Bay K 8644 elevate intracellular calcium concentrations. This rise in calcium levels can trigger various calcium-dependent signaling cascades that might enhance the activity of TMEM206. Anandamide operates through the endocannabinoid system to modulate ion channels that may interact with TMEM206, while 1-EBIO and NS1619, by activating potassium channels, alter the electrochemical gradient across the cell membrane, potentially influencing TMEM206 activity.
Additional TMEM206 activators include Pregnenolone sulfate and Zn2+, which exert their effects by modulating ionotropic receptors and ion channels, potentially leading to enhanced TMEM206 activity. Bithionol impacts chloride channels, impacting the ionic balance and indirectly influencing TMEM206 function. Clofilium tosylate, a potassium channel blocker, alters the membrane potential, which could indirectly lead to the enhancement of TMEM206 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can activate PKA. PKA then phosphorylates various proteins, potentially including TMEM206, to enhance its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that prevents the breakdown of cAMP and cGMP, thereby sustaining their action and enhancing PKA activity, which may indirectly activate TMEM206. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644 is a dihydropyridine compound that acts as an L-type calcium channel activator, indirectly promoting calcium-dependent processes that could enhance TMEM206 function. | ||||||
Irbesartan | 138402-11-6 | sc-218603 sc-218603A | 10 mg 50 mg | $104.00 $297.00 | 3 | |
1-EBIO activates small conductance Ca2+-activated K+ (SK) channels, which may indirectly influence the activity of TMEM206 by altering cellular electrochemical gradients. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $97.00 | 2 | |
Pregnenolone sulfate modulates various ionotropic receptors and could potentiate TMEM206 activity through downstream effects on ion homeostasis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can act as allosteric modulators of various ion channels and receptors; they may enhance TMEM206 activity by affecting channels that indirectly interact with TMEM206. | ||||||
Bithionol | 97-18-7 | sc-239383 | 25 g | $77.00 | ||
Bithionol modulates chloride channels, which could affect the ionic environment and indirectly enhance the functional activity of TMEM206. | ||||||
Clofilium tosylate | 92953-10-1 | sc-391228 sc-391228A | 25 mg 100 mg | $428.00 $1020.00 | 1 | |
Clofilium tosylate is a potassium channel blocker that could influence the membrane potential and indirectly enhance TMEM206 activity by altering the electrochemical gradient. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
Ciclopirox olamine has multiple cellular targets but can modulate metal ion homeostasis, which may indirectly enhance TMEM206 function by altering ion channel activity. | ||||||