TMEM184B Inhibitors
TMEM184B Inhibitors comprise a set of compounds that indirectly curb the functional activity of TMEM184B, a protein involved in calcium signaling. These inhibitors predominantly operate by disrupting the calcium signaling pathway, thereby affecting the functional activity of TMEM184B. For example, U73122, an inhibitor of phospholipase C, suppresses the generation of inositol trisphosphate, a crucial component for calcium release. This action alters TMEM184B's function since it regulates calcium signaling. Similarly, 2-APB, an inhibitor of IP3 receptors, can impact TMEM184B's functional activity by decreasing calcium signaling.
Several TMEM184B Inhibitors function by directly blocking calcium channels or altering calcium concentration. These include Nifedipine and Verapamil, both calcium channel blockers that inhibit calcium ions' influx. By decreasing calcium ion concentration, they can inhibit TMEM184B's associated function. Similarly, BAPTA-AM, a cell-permeable calcium chelator, by reducing intracellular calcium, can inhibit TMEM184B'sfunction related to calcium regulation. In the same category, Ziconotide, a potent blocker of N-type calcium channels, and Felodipine, another calcium channel blocker, inhibit TMEM184B's function by preventing calcium influx.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a non-specific inhibitor of IP3 receptors. IP3 receptors are responsible for calcium release from the ER. By inhibiting these receptors, 2-APB can decrease calcium signaling, potentially impacting TMEM184B's functional activity through its role in calcium regulation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions through L-type voltage-gated calcium channels. By reducing calcium ion concentration, it can potentially inhibit TMEM184B's function related to calcium signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pumps. By inhibiting SERCA, Thapsigargin disrupts calcium homeostasis, which could impact the function of TMEM184B due to its role in calcium regulation. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator. By chelating extracellular calcium, it can decrease intracellular calcium levels, potentially inhibiting TMEM184B's function related to calcium regulation. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry. By inhibiting calcium influx into the cells, SKF-96365 can potentially affect TMEM184B's function, which is known to be involved in calcium signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is another calcium channel blocker that inhibits the influx of calcium ions. By reducing calcium ion concentration, it can potentially inhibit TMEM184B's function related to calcium regulation. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red inhibits calcium uptake into mitochondria. By disrupting mitochondrial calcium homeostasis, it can potentially inhibit the functional activity of TMEM184B, which is involved in calcium regulation. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, which control calcium release from the ER. By inhibiting these receptors, Dantrolene can potentially affect TMEM184B's functional activity through its role in calcium regulation. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
TMB-8 inhibits IP3-mediated calcium release. By inhibiting the release of calcium from the ER, TMB-8 can potentially inhibit the functional activity of TMEM184B, which is involved in calcium signaling. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Felodipine is another calcium channel blocker that inhibits the influx of calcium ions. By reducing calcium ion concentration, it can potentially inhibit TMEM184B's function related to calcium regulation. | ||||||