TMEM184B Antibody (A-6): sc-515425
- TMEM184B Antibody (A-6) is a mouse monoclonal IgG1 κ TMEM184B antibody provided at 200 µg/ml
- raised against amino acids 340-398 mapping near the C-terminus of TMEM184B of human origin
- TMEM184B Antibody (A-6) is recommended for detection of TMEM184B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TMEM184B Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMEM184B Antibody (A-6) for WB applications. These reagents are now offered in bundles with TMEM184B Antibody (A-6) (see ordering information below).
QUICK LINKS
TMEM184B Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMEM184B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMEM184B (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEM184B, also known as FM08, HS5O6A, or C22orf5, is a 407 amino acid multi-pass membrane protein that plays a crucial role in activating the mitogen-activated protein kinase (MAPK) signaling pathway, which is essential for various cellular processes, including growth, differentiation, and response to stress. TMEM184B is encoded on human chromosome 22, a region associated with several genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2. Mutations in genes on chromosome 22 can contribute to autism and schizophrenia development, highlighting TMEM184B′s importance in neurodevelopmental processes. Translocations involving chromosome 22 can lead to Philadelphia Chromosome formation, resulting in BCR-Abl fusion protein production, a significant driver of cell proliferation in various leukemias.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMEM184B Antibody (A-6) References:
- Chromosome 22 workshop report. | Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
- Disease genes and chromosomes: disease maps of the human genome. Chromosome 22. | Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. | Matsuda, A., et al. 2003. Oncogene. 22: 3307-18. PMID: 12761501
- Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2. | Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
- Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. | Paylor, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 7729-34. PMID: 16684884
- Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia. | Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
- Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings. | Ahronowitz, I., et al. 2007. Hum Mutat. 28: 1-12. PMID: 16983642
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. | Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
- Deletion 22q11: spectrum of associated disorders. | Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMEM184B Antibody (A-6) | sc-515425 | 200 µg/ml | $316.00 | |||
TMEM184B Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-531359 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMEM184B Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-525031 | 200 µg Ab, 40 µg BP | $354.00 | |||
TMEM184B Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-544503 | 200 µg Ab; 20 µg BP | $354.00 | |||
TMEM184B Antibody (A-6) AC | sc-515425 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TMEM184B Antibody (A-6) HRP | sc-515425 HRP | 200 µg/ml | $316.00 | |||
TMEM184B Antibody (A-6) FITC | sc-515425 FITC | 200 µg/ml | $330.00 | |||
TMEM184B Antibody (A-6) PE | sc-515425 PE | 200 µg/ml | $343.00 | |||
TMEM184B Antibody (A-6) Alexa Fluor® 488 | sc-515425 AF488 | 200 µg/ml | $357.00 | |||
TMEM184B Antibody (A-6) Alexa Fluor® 546 | sc-515425 AF546 | 200 µg/ml | $357.00 | |||
TMEM184B Antibody (A-6) Alexa Fluor® 594 | sc-515425 AF594 | 200 µg/ml | $357.00 | |||
TMEM184B Antibody (A-6) Alexa Fluor® 647 | sc-515425 AF647 | 200 µg/ml | $357.00 | |||
TMEM184B Antibody (A-6) Alexa Fluor® 680 | sc-515425 AF680 | 200 µg/ml | $357.00 | |||
TMEM184B Antibody (A-6) Alexa Fluor® 790 | sc-515425 AF790 | 200 µg/ml | $357.00 |