TMEM150C Inhibitors
TMEM150C, encoding a transmembrane protein crucial for mechanosensitive ion channels, plays a pivotal role in various cellular processes, including hearing, touch, pain perception, and blood pressure regulation. The gene confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons, highlighting its significance in sensory and physiological functions. TMEM150C's activation relies on mechanical stimuli, making it a key sensor for environmental cues. Inhibition of TMEM150C can be achieved through various mechanisms, either directly or indirectly. Direct inhibitors, such as GsMTx-4, interact with the mechanosensitive ion channel, impeding its activation by disrupting conformational changes induced by mechanical stimuli. Indirect inhibitors, like Ruthenium Red and Gadolinium chloride, interfere with calcium signaling pathways essential for TMEM150C function. Amiloride disrupts sodium-proton exchangers, SKF-96365 blocks store-operated calcium channels, and Dynasore affects endocytosis, all leading to impaired TMEM150C mechanosensitivity.
ML-7 targets myosin light chain kinase, influencing the actin cytoskeleton dynamics crucial for TMEM150C activation. Pyr3 modulates purinergic receptors, Yoda1 hyperactivates alternative channels, and Pyridoxal-5'-phosphate alters pyridoxal kinase-mediated processes. Chlorpromazine affects membrane fluidity, and the Rho kinase inhibitor Y-27632 disrupts the Rho/ROCK pathway, impacting actin cytoskeleton dynamics and, consequently, TMEM150C mechanosensitivity. In summary, understanding TMEM150C's vital role in mechanosensitive ion channels provides a foundation for exploring inhibition strategies.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red, a transition metal complex, indirectly inhibits TMEM150C by blocking calcium ions. As TMEM150C's activation involves calcium influx, this compound disrupts the ion channel's response to mechanical stimuli. The inhibition occurs through the modulation of calcium signaling pathways essential for TMEM150C function. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Gadolinium chloride acts as an indirect inhibitor of TMEM150C by impeding mechanosensitive ion channels' activation through inhibition of stretch-activated channels. This disrupts the normal functioning of TMEM150C, as its activation is closely linked to mechanical stimuli and stretch-activated channels. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $296.00 | 7 | |
Amiloride, a diuretic, indirectly inhibits TMEM150C by suppressing sodium-proton exchangers. As TMEM150C activity is modulated by changes in intracellular sodium levels, amiloride disrupts this balance, affecting the mechanosensitivity of the ion channel and hindering its normal function. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 acts as an indirect inhibitor of TMEM150C by blocking store-operated calcium channels. Since TMEM150C's activation involves calcium signaling, this compound disrupts the ion channel's response to mechanical stimuli by interfering with the availability of intracellular calcium. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore, a dynamin inhibitor, indirectly inhibits TMEM150C by disrupting endocytosis. TMEM150C undergoes endocytosis for proper functioning, and dynasore interferes with this process, leading to abnormal localization or reduced expression of TMEM150C on the cell membrane, thereby inhibiting its mechanosensitive activation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an indirect inhibitor of TMEM150C that affects myosin light chain kinase. By inhibiting this kinase, ML-7 disrupts the actin cytoskeleton dynamics, which are crucial for TMEM150C activation. The altered cytoskeletal structure impedes the mechanical forces' transmission, affecting the ion channel's responsiveness to mechanical stimuli. | ||||||
Pyr3 | 1160514-60-2 | sc-301624 sc-301624A sc-301624B | 5 mg 10 mg 25 mg | $151.00 $260.00 $520.00 | ||
Pyr3 is an indirect inhibitor of TMEM150C that targets purinergic receptors. As TMEM150C activation involves purinergic signaling, Pyr3 interferes with this pathway, modulating the ion channel's response to mechanical stimuli. The inhibition occurs through the disruption of purinergic-mediated events crucial for TMEM150C function. | ||||||
YODA 1 | 448947-81-7 | sc-507361 | 10 mg | $215.00 | ||
Yoda1, a selective activator of mechanosensitive ion channels, indirectly inhibits TMEM150C by hyperactivating other channels. The heightened activity of alternative channels induces desensitization or adaptation mechanisms in cells, negatively impacting TMEM150C's responsiveness to mechanical stimuli and inhibiting its normal function. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal-5'-phosphate, the active form of vitamin B6, indirectly inhibits TMEM150C by modulating pyridoxal kinase. As TMEM150C function is influenced by pyridoxal kinase-mediated processes, alterations induced by pyridoxal-5'-phosphate disrupt the ion channel's response to mechanical stimuli, leading to inhibition of its mechanosensitive activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine, an antipsychotic drug, indirectly inhibits TMEM150C by affecting membrane fluidity. Changes in membrane fluidity impact the mechanosensitive properties of the ion channel, disrupting its activation in response to mechanical stimuli. Chlorpromazine-induced alterations in membrane properties directly influence TMEM150C function, resulting in inhibition. | ||||||