TMEM143 Activators
TLR11 activators predominantly function by influencing the toll-like receptors (TLRs), an essential part of the innate immune system that recognizes molecular patterns associated with pathogens. Upon activation, TLRs can initiate innate immune responses, which can enhance the functional activity of TLR11. Chemical compounds such as Resiquimod, Imiquimod, and Poly(I:C) are known to activate specific TLRs and could activate TLR11. These compounds, upon binding to TLRs, can trigger signaling cascades that lead to the production of pro-inflammatory cytokines and type I interferons, thus enhancing the functional activity of TLR11.
Furthermore, other compounds like Pam3CSK4, Flagellin, Lipopolysaccharides (LPS), Zymosan, CL075, R848, CL097, and Gardiquimod are known to activate specific TLRs and could potentially activate TLR11. The activation of TLRs by these compounds initiates innate immune responses, enhancing the functional activity of TLR11. For example, LPS, a component of the outer membrane of Gram-negative bacteria, canactivate TLR4 and, by similarity, could activate TLR11. Similarly, flagellin can activate TLR5 and possibly TLR11. These activations trigger signaling cascades that result in the production of pro-inflammatory cytokines and chemokines, thereby enhancing the functional activity of TLR11.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $100.00 $300.00 $500.00 $1528.00 | 12 | |
Resiquimod is a TLR7 and TLR8 agonist that can potentially also activate TLR11. The activation of TLRs leads to the initiation of innate immune responses, which can enhance the functional activity of TLR11. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $66.00 $278.00 | 6 | |
Imiquimod is a TLR7 agonist that can possibly activate TLR11, thereby enhancing its functional activity. The activation of TLRs results in the initiation of innate immune responses. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $194.00 | ||
Poly(I:C) is a synthetic analog of double-stranded RNA that can activate TLR3, and potentially TLR11. The activation of TLRs leads to the initiation of innate immune responses, enhancing the functional activity of TLR11. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
Pam3CSK4 is a synthetic triacylated lipopeptide that is a TLR1/2 agonist and could potentially activate TLR11. The activation of TLRs initiates innate immune responses, enhancing the functional activity of TLR11. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $96.00 $166.00 $459.00 $1615.00 | 12 | |
Lipopolysaccharides (LPS) are components of the outer membrane of Gram-negative bacteria that activate TLR4 and could potentially activate TLR11. Activation of TLRs initiates innate immune responses, enhancing the functional activity of TLR11. | ||||||
Zymosan | 9010-72-4 | sc-296863 sc-296863A | 100 mg 1 g | $97.00 $587.00 | 1 | |
Zymosan, a glucan with repeating glucose units, activates TLR2 and TLR6 and could potentially activate TLR11. Activation of TLRs initiates innate immune responses, enhancing the functional activity of TLR11. | ||||||
CL097 | 1026249-18-2 | sc-507394 | 5 mg | $135.00 | ||
CL097 is a water-soluble derivative of CL075 that acts as an agonist for TLR7/8 and could potentially activate TLR11. Activation of TLRs initiates innate immune responses, enhancing the functional activity of TLR11. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $154.00 $276.00 $506.00 $1154.00 $19743.00 $32136.00 $69366.00 | 1 | |
Gardiquimod is a specific TLR7 agonist, which could potentially activate TLR11. The activation of TLRs initiates innate immune responses, enhancing the functional activity of TLR11. | ||||||