TMEM140 Inhibitors
TMEM140 inhibitors are a class of chemical compounds designed to interact with the transmembrane protein 140 (TMEM140), which is a protein encoded by the human gene of the same name. The role of TMEM140 within cellular biology is not entirely elucidated, but it is known to be involved in various cellular processes due to its presence within the cell membrane. As with many transmembrane proteins, TMEM140 traverses the lipid bilayer of cells, making it accessible from both the intracellular environment and the extracellular space. The inhibitors targeting TMEM140 are therefore crafted to modulate the function of this protein by binding to it in a specific manner, affecting its natural activity within the cell. The exact mechanism of action of these inhibitors can vary, often depending on the structure of the inhibitor and the specific domain of the protein they are designed to interact with.
Chemically, TMEM140 inhibitors are diverse, as they can be found in a range of chemical scaffolds with differing properties to ensure optimal interaction with the protein. Their design takes into account the unique topology and electrostatic environment of the TMEM140 protein to achieve selectivity and reduce off-target effects. Researchers in the field of medicinal chemistry synthesize these inhibitors through a variety of methods, often utilizing high-throughput screening to identify promising candidates from large chemical libraries. Structure-activity relationship (SAR) studies are fundamental in this process, guiding the modification of chemical moieties within the inhibitors to refine their potency and selectivity. The physical properties of these inhibitors, such as solubility, stability, and permeability, are also critical considerations, as they influence the compound's ability to reach and maintain effective concentrations at the site of the TMEM140 protein. Overall, TMEM140 inhibitors represent a focused area within chemical biology, where the intersection of chemistry, biology, and structural science converge to explore the modulation of specific protein functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which blocks the MAPK/ERK pathway. TMEM140 has been implicated in the regulation of cell proliferation through ERK-dependent signaling. Inhibition of the MAPK/ERK pathway by PD98059 could therefore lead to the reduced activity of TMEM140 by preventing its associated proliferative signals. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. PI3K signaling is crucial for multiple cellular functions, including growth and survival. TMEM140 is thought to be involved in similar cellular processes, and the inhibition of PI3K activity by LY294002 could indirectly decrease the functional activity of TMEM140 by disrupting these pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. By inhibiting p38 MAPK, it disrupts the stress-activated MAPK pathway. TMEM140, through its role in cellular stress responses, may have its activity modulated by changes in this signaling pathway, leading to a decrease in its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK signaling is involved in the regulation of apoptosis and cell differentiation. TMEM140 could be indirectly affected by JNK inhibition due to its potential involvement in these cellular processes, reducing TMEM140's functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. By blocking PI3K signaling, it interferes with various cellular functions, including proliferation, growth, and survival. TMEM140's activity could be hindered by the disruption of PI3K pathways due to Wortmannin, leading to decreased functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, which impedes the mTOR signaling pathway important for cell growth, proliferation, and survival. As TMEM140 is implicated in similar cellular processes, its activity could be indirectly reduced through the inhibition of mTOR signaling by Rapamycin. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a broad-spectrum protein kinase C (PKC) inhibitor. PKC is involved in various signaling pathways that regulate cell proliferation and survival. The inhibition of PKC by Go6983 could lead to decreased TMEM140 activity, as TMEM140 may be involved in PKC-regulated processes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is another potent PKC inhibitor. It blocks the activity of PKC isozymes, which could lead to a reduction in TMEM140 function by altering the PKC-mediated signaling pathways that TMEM140 may participate in. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective MEK inhibitor that prevents the activation of ERK1/2 kinases, thereby inhibiting the MAPK/ERK pathway. This could lead to a functional inhibition of TMEM140 by impeding ERK-dependent mechanisms that TMEM140 may be involved in. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-kappaB activation. NF-kappaB plays a crucial role in inflammatory responses and cell survival. Inhibition of NF-kappaB by BAY 11-7082 could negatively impact TMEM140 activity if TMEM140 is involved in NF-kappaB-mediated signaling processes. | ||||||