TMEM130 Inhibitors
TMEM130 inhibitors represent a category of chemical compounds designed to interact with the transmembrane protein 130 (TMEM130), which is a part of a larger family of proteins known as transmembrane proteins. These proteins span the entire lipid bilayer of the cell membrane, serving as gatekeepers and communicators between the cell's interior and its external environment. The specific function of TMEM130 within this family is not fully characterized, but proteins in this category often play critical roles in various cellular processes. TMEM130 inhibitors are structured to bind selectively to the TMEM130 protein, thereby affecting its normal function. The design of these inhibitors is based on the understanding of the protein's structure and the biological pathways it might be involved in. By binding to TMEM130, these inhibitors can alter the protein's configuration or its ability to interact with other molecules, which can lead to a cascade of effects at the molecular level.
The development of TMEM130 inhibitors involves sophisticated chemical synthesis and molecular biology techniques. Researchers utilize high-throughput screening methods to identify potential compounds that show activity against TMEM130. These initial compounds are often refined through a process known as medicinal chemistry to improve their selectivity and potency while reducing any unintended interactions with other proteins. The molecular structure of TMEM130 inhibitors typically features a combination of hydrophobic and hydrophilic elements, allowing them to associate with the lipid-rich cell membrane while also interacting with the specific polar or charged amino acid residues of the protein. Advanced techniques such as X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy may be employed to elucidate the precise interaction between the inhibitor and the TMEM130 protein. This detailed understanding aids in the refinement of the inhibitor's structure, ensuring that it can effectively target the TMEM130 protein without interacting with other proteins that share similar structural motifs.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. PI3K signaling is crucial for many cellular processes. By inhibiting PI3K, wortmannin can decrease the activity of downstream targets, including AKT. As TMEM130 has been implicated in cellular processes that are affected by AKT signaling, inhibition of PI3K could lead to a reduction in TMEM130 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, similar to wortmannin. It blocks the kinase activity of PI3K, leading to a decrease in AKT phosphorylation and activity. Given that TMEM130's function may be influenced by AKT signaling, LY294002 can indirectly inhibit TMEM130 activity by disrupting this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that interacts with the mTORC1 complex to inhibit downstream signaling pathways. Since mTOR is a central regulator of cell growth and autophagy, its inhibition could indirectly affect TMEM130 function, especially if TMEM130 is involved in processes regulated by mTOR. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, which is involved in the response to stress and inflammatory cytokines. Inhibition of p38 MAPK can alter cellular responses and indirectly affect the functional activity of TMEM130 if it is involved in these stress-related pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream activators of ERK1/2 in the MAPK pathway. By inhibiting MEK, U0126 prevents the activation of ERK, potentially modifying the functional activity of TMEM130 if it is linked to the ERK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of the c-Jun N-terminal kinase (JNK), which plays a role in regulating apoptosis, cell differentiation, and proliferation. Inhibition of JNK signaling can indirectly decrease TMEM130 activity if TMEM130 is connected to JNK-regulated cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that blocks the activation of ERK1/2. By disrupting the MAPK/ERK pathway, PD98059 could influence TMEM130 function indirectly, assuming TMEM130's activity is modulated through this signaling cascade. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), which is required for vesicle formation in the Golgi apparatus. As TMEM130 is a transmembrane protein, interference with Golgi function could indirectly impair its processing and activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin, thereby preventing the dephosphorylation and nuclear translocation of NFAT. If TMEM130 activity is connected to calcineurin/NFAT signaling, Cyclosporin A could indirectly inhibit TMEM130. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC). PKC is involved in various cellular processes, including cell proliferation and death. If TMEM130 is modulated by PKC-mediated signaling, chelerythrine could reduce its functional activity. | ||||||