Date published: 2025-10-23

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TMEM116 Activators

TMEM116 Activators constitute a specialized class of chemicals designed to enhance the expression or functionality of Transmembrane Protein 116 (TMEM116). This diverse group features various molecular structures, each uniquely influencing TMEM116, a protein pivotal in cellular communication. The activation of TMEM116 by these substances is crucial, impacting key biological functions, such as cell signaling and environmental interactions. TMEM116 Activators work through multiple mechanisms, including direct interaction with TMEM116, altering its gene expression, or modulating associated signaling pathways.

The action of these activators ranges from binding directly to TMEM116, altering its structure or activity, to indirectly influencing transcriptional machinery to boost TMEM116 expression. This might involve epigenetic alterations, making the TMEM116 gene more accessible for transcription. In other cases, TMEM116 Activators affect upstream signaling molecules or pathways, which in turn, influence TMEM116 expression or function. This could involve the activation or inhibition of specific enzymes crucial to signaling pathways linked to TMEM116. The effects of these activators extend beyond TMEM116, potentially impacting related proteins and cellular signaling networks. Studying TMEM116 Activators is important for understanding cell and molecular biology, especially in terms of cellular communication and membrane biology. By examining how these chemicals impact TMEM116, researchers gain insights into the intricate signaling pathways that control cellular functions. Ongoing research in this area promises to identify new TMEM116 Activators, furthering our knowledge of cellular signaling processes and the roles of transmembrane proteins.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cobalt(II) chloride

7646-79-9sc-252623
sc-252623A
5 g
100 g
$63.00
$173.00
7
(1)

CoCl2 might induce TMEM116 expression by simulating hypoxic conditions that can upregulate certain genes.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

This HDAC inhibitor could increase TMEM116 expression by promoting a more transcriptionally active chromatin state.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

May upregulate TMEM116 by demethylating DNA and activating genes that are otherwise silenced.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Known to increase cAMP levels, which could lead to the upregulation of various genes, including potentially TMEM116.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Involved in gene regulation; could upregulate TMEM116 as part of broader changes in gene expression.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

Its role in gene regulation and cellular growth might extend to the upregulation of TMEM116 in certain cell types.

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$62.00
$178.00
8
(1)

In hormone-responsive tissues, estrogen could upregulate TMEM116 as part of its broad effects on gene expression.

Progesterone

57-83-0sc-296138A
sc-296138
sc-296138B
1 g
5 g
50 g
$20.00
$51.00
$292.00
3
(1)

Similar to estrogen, might upregulate TMEM116 in hormone-responsive cells.