TMEM100 Inhibitors
As TMEM100 is implicated in the TGF-β pathway, the inhibitors are commonly involved in blocking the activity of TGF-β receptors or their related kinases. This group of inhibitors includes small molecules that can selectively inhibit receptor kinases like ALK4, and ALK7, which are known to mediate the cellular responses to TGF-β signaling, thereby influencing the role of TMEM100 indirectly. Additionally, some chemicals within this class function by impeding the phosphorylation of Smad proteins, which are critical mediators of TGF-β signal transduction to the nucleus. By doing so, they may alter the functional outcomes of TMEM100's modulation of TGF-β signaling.
The chemical structures of these inhibitors vary, but they often share a common trait in their ability to bind to active sites or allosteric sites on their target receptors or enzymes, leading to inhibition of the TGF-β signaling pathway. This indirect approach to affecting TMEM100's activity provides a means to modulate its function within the cell, with each inhibitor having a distinct profile based on its specificity, potency, and selectivity towards different components of the TGF-β pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
A selective inhibitor of ALK5, ALK4, and ALK7, which are receptors in the TGF-β pathway, potentially reducing TMEM100-mediated signaling. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
An inhibitor of ALK5, ALK4, and ALK7, which might decrease TMEM100 activity through the inhibition of TGF-β signaling. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
A potent ALK5 inhibitor, which could suppress TMEM100 signaling by attenuating the TGF-β pathway. | ||||||
ITD 1 | 1099644-42-4 | sc-507349 | 10 mg | $220.00 | ||
A selective TGF-β receptor inhibitor, which may decrease TMEM100-related signaling by disrupting TGF-β-mediated cellular responses. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
An antiallergic drug known to inhibit TGF-β release and could indirectly decrease TMEM100 activity by reducing TGF-β signaling. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
An inhibitor of Smad3 phosphorylation, a downstream component of the TGF-β pathway, which may in turn affect TMEM100 signaling. | ||||||