TMEM100 Activators
A class of chemicals called TMEM100 Activators centers on compounds that modulate the TGF-beta signaling pathway. These chemicals can indirectly activate TMEM100, a protein that plays a significant role in this pathway. The primary method of activation is through the modulation of the TGF-beta signaling pathway, either by direct stimulation using chemicals such as TGF-beta1 or by inhibiting specific components of the pathway like ALK5, TGF-beta receptor I. For instance, chemicals like LY2157299, and RepSox are potent and selective inhibitors of ALK5, which can upregulate the pathway and thus indirectly activate TMEM100.
Most of these chemicals work by selectively inhibiting the TGF-beta receptor I, also known as ALK5. By doing so, they can stimulate the TGF-beta signaling pathway, leading to the indirect activation of TMEM100. Some act as anti-fibrotic agents, like Pirfenidone, which inhibits TGF-beta and can modulate the signaling pathway, leading to the indirect activation of TMEM100. In summary, the TMEM100 Activators class consists of chemicals impacting the TGF-beta signaling pathway, thereby influencing TMEM100 indirectly. However, it's important to note that the effect on TMEM100 is indirect and an outcome of broader pathway modulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299 is a selective TGF-beta receptor I kinase inhibitor, its inhibition can modulate the TGF-beta signaling pathway, indirectly leading to the activation of TMEM100. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
ALK5 Inhibitor II (RepSox) is a selective inhibitor of the TGF-β type I receptor ALK5, its inhibition can stimulate the TGF-beta signaling pathway, indirectly leading to the activation of TMEM100. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
TGF-β RI Kinase Inhibitor V (SD208) is a selective inhibitor of TGF-beta receptor I (ALK5), its inhibition can upregulate the TGF-beta signaling pathway, indirectly leading to the activation of TMEM100. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $327.00 $1377.00 | 2 | |
SB505124 is a selective inhibitor of TGF-beta Receptor type I (ALK5), ALK7, and ALK4, its inhibition can stimulate the TGF-beta signaling pathway, indirectly leading to the activation of TMEM100. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Pirfenidone is an anti-fibrotic agent that inhibits TGF-beta, its inhibition can modulate the TGF-beta signaling pathway, indirectly leading to the activation of TMEM100. | ||||||