TLR8 Inhibitors
TLR8 inhibitors belong to a specific chemical class designed to modulate the activity of Toll-like receptor 8 (TLR8), a crucial component of the innate immune system. TLR8 is a member of the Toll-like receptor family, which plays a fundamental role in detecting pathogens and initiating immune responses. TLR8 is primarily expressed in immune cells, such as dendritic cells and monocytes, and is responsible for recognizing single-stranded RNA molecules from viruses and certain bacteria. Upon activation, TLR8 triggers a signaling cascade that leads to the production of pro-inflammatory cytokines and type I interferons, which are essential for mounting an immune response against invading pathogens.
TLR8 inhibitors are designed to interfere with this signaling pathway by binding to TLR8 and preventing its activation. They do so by targeting specific molecular sites on the receptor, such as its ligand-binding domain or intracellular signaling domains. By inhibiting TLR8 activation, these compounds can modulate the immune response, reducing excessive inflammation and preventing immune-mediated tissue damage. This makes TLR8 inhibitors a valuable tool for researchers studying the immune system and its role in various diseases, as they allow for the precise manipulation of immune responses in experimental settings. Furthermore, understanding TLR8 inhibitors' mechanisms of action can shed light on the intricate workings of the innate immune system and lead to the development of novel strategies for conditions where immune dysregulation plays a central role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an aminoquinoline that has been shown to inhibit endosomal maturation. Since TLR8 functions in the endosomal compartment and recognizes ssRNA, chloroquine's ability to disrupt endosomal acidification and maturation can potentially impede TLR8's ability to effectively interact with its ligands, leading to a decrease in its activation. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine Sulfate is an aminoquinoline that can disrupt endosomal acidification. This interference can inhibit the proper functioning of TLR8, as it relies on the acidic environment of the endosome for ligand recognition and subsequent signaling. | ||||||
Quinacrine, Dihydrochloride | 69-05-6 | sc-204222 sc-204222B sc-204222A sc-204222C sc-204222D | 100 mg 1 g 5 g 200 g 300 g | $46.00 $57.00 $87.00 $3257.00 $4821.00 | 4 | |
Quinacrine, Dihydrochloride is an acridine derivative with properties similar to chloroquine. It can disrupt lysosomal activity and endosomal maturation, potentially affecting the normal functioning of TLR8 in the endosomal compartment and leading to a reduction in its expression and activity. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a macrolide antibiotic known to inhibit vacuolar-type H+-ATPase, disrupting endosomal acidification. This disruption can lead to impaired TLR8 signaling, as TLR8 requires an acidic endosomal environment to properly interact with ssRNA and initiate downstream signaling pathways. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A is another vacuolar-type H+-ATPase inhibitor. By disrupting the acidification of endosomes, it can potentially impede TLR8’s ability to recognize ssRNA and initiate the appropriate immune responses, leading to a decrease in TLR8 expression and activity. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $62.00 | 8 | ||
This solution can raise the pH of acidic organelles, including endosomes. This change in pH can affect the functionality of TLR8, as it requires an acidic environment for proper ligand recognition and signaling. As a result, the expression and activity of TLR8 may be reduced. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine is a phenothiazine antipsychotic that can affect endocytosis and lysosomal function. Its potential to disrupt endosomal maturation and function may lead to impaired TLR8 signaling, contributing to a decrease in TLR8 expression and activity. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin A is a polyether antibiotic that disrupts intracellular ion transport and can affect endosomal acidification. This interference may impede the normal functioning of TLR8, potentially leading to reduced expression and activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol with various biological activities. While its exact mechanism on TLR8 is not fully understood, it has been shown to modulate immune responses and could potentially influence TLR8 expression and activity indirectly through effects on other signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound with anti-inflammatory properties. It can modulate various signaling pathways and has the potential to indirectly affect TLR8 expression and activity, though the exact mechanisms remain to be fully elucidated. | ||||||