TLK2 Activators
TLK2 activators belong to a unique chemical class characterized by their ability to modulate the activity of a specific protein known as TLK2 (Tousled-Like Kinase 2). TLK2 is a serine/threonine kinase that plays a crucial role in various cellular processes, particularly in the regulation of DNA repair, cell cycle progression, and chromatin structure. The development of small molecules that can activate TLK2 has garnered considerable interest within the scientific community due to the potential insights they offer into fundamental cellular mechanisms.
The structural and functional characteristics of TLK2 activators vary, but they typically share a common feature of enhancing the kinase activity of TLK2. By binding to TLK2 or interacting with its substrates, these molecules promote phosphorylation events crucial for DNA repair, cell cycle control, and chromatin remodeling. This molecular manipulation has significant implications in understanding the molecular intricacies of these biological processes and may open doors to innovative research in fields such as genomics, cancer biology, and regenerative medicine. Researchers are continually exploring the precise mechanisms by which TLK2 activators function and their broader implications for basic science, potentially uncovering novel avenues for investigating cellular biology and its intricacies.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
Activates TLK2 by inhibiting DNA-dependent protein kinase, potentially enhancing DNA repair pathways. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $243.00 $1015.00 | 1 | |
Enhances TLK2 activity by inhibiting ATM kinase, a component of DNA damage response pathways, indirectly affecting TLK2 through shared signaling networks. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
Activates TLK2 by inhibiting ATR kinase involved in DNA damage checkpoint pathways, thereby influencing TLK2 through interconnected cellular processes. | ||||||
LY2603618 | 911222-45-2 | sc-364526 sc-364526A | 5 mg 50 mg | $214.00 $1809.00 | ||
Promotes TLK2 activation by targeting Chk1, which is involved in DNA damage response and cell cycle regulation. This indirect activation influences TLK2 activity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Activates TLK2 by inhibiting CDKs, which regulate the cell cycle. This activation indirectly affects TLK2 by modulating cell cycle progression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Enhances TLK2 activity by targeting topoisomerases involved in DNA replication and repair, promoting activation of TLK2 through DNA repair processes. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Modifies base excision repair pathways by targeting PARP, potentially promoting TLK2 activation indirectly through DNA repair processes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Activates TLK2-mediated chromatin regulation by altering chromatin structure through the inhibition of histone deacetylases. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Promotes TLK2 activation by modifying DNA methylation patterns, potentially influencing TLK2's role in epigenetic regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Activates TLK2-mediated cell cycle control by impacting mTOR signaling linked to cell growth and proliferation. | ||||||