TIMAP inhibitors, short for T-lymphocyte invasion and metastasis protein inhibitors, belong to a distinctive class of chemical compounds that target a specific protein implicated in cellular processes related to immune response and cancer progression. The T-lymphocyte invasion and metastasis-associated protein (TIMAP) is a signaling molecule that plays a crucial role in regulating cellular functions, particularly in the context of immune cell activity and the metastatic behavior of cancer cells. The inhibitors designed to interact with TIMAP operate at the molecular level, modulating the protein's activity and disrupting the intricate signaling pathways in which it is involved.
TIMAP inhibitors are characterized by specific molecular features that enable them to bind selectively to the TIMAP protein. These compounds often possess functional groups and three-dimensional arrangements that facilitate precise interactions with the target, influencing its conformation or blocking key binding sites. This targeted interaction is crucial for their efficacy and specificity, as it allows TIMAP inhibitors to interfere with the protein's normal function without affecting unrelated cellular processes. The development and refinement of TIMAP inhibitors represent a significant stride in the field of chemical biology, providing researchers with valuable tools to investigate the intricate mechanisms underlying immune responses and cancer metastasis
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits ALK5, ALK4, and ALK7, which are receptors involved in TGF-beta signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
HTS inhibitor that selectively targets TGF-beta type I receptor kinase, impacting the pathway. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
Selectively inhibits ALK5, ALK4, and ALK7, thus affecting TGF-beta-related signaling. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
TGF-beta receptor I kinase inhibitor, alters downstream signaling related to the receptor. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
Inhibits TGF-beta type I receptor kinase, altering TGF-beta signaling and related activities. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
Selectively inhibits TGF-beta receptor I, thereby modulating the TGF-beta signaling pathway. | ||||||
GW788388 | 452342-67-5 | sc-363544 sc-363544A | 5 mg 25 mg | $95.00 $384.00 | ||
Inhibits both TGF-beta type I receptor kinase and ALK5, impacting signaling. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
It has been shown to downregulate TGF-beta, affecting its signaling cascade. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $30.00 $101.00 $277.00 $959.00 | 2 | |
Alters TGF-beta expression and release, thus modulating its signaling pathways. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
Inhibits ALK5 kinase activity, which is essential for TGF-beta signal transduction. | ||||||