TIMAP Activators
TIMAP Activators refer to a specific class of chemical compounds that have garnered significant attention in the field of molecular biology and cell signaling research. These compounds are known for their unique ability to modulate the activity of TIMAP, which stands for TGFβ-activated kinase 1 (TAK1/MAP3K7)-binding protein. TIMAP itself is a crucial protein involved in various cellular processes, particularly those related to the regulation of intracellular signaling pathways. TIMAP Activators, as the name suggests, are small molecules that can interact with TIMAP and influence its functions within the cell.TIMAP Activators exhibit a high degree of specificity in their interactions with TIMAP. They are designed to bind to specific regions of TIMAP, leading to conformational changes that can either enhance or inhibit its activity. This modulation of TIMAP's activity has downstream effects on several signaling pathways, including those involved in cell growth, proliferation, and differentiation. Researchers have been particularly interested in understanding the structural basis of the interaction between TIMAP Activators and TIMAP, as this knowledge can provide insights into the precise mechanisms through which these compounds exert their effects.
TIMAP Activators have shed light on their potential as valuable tools for investigating the intricacies of cellular signaling cascades. By manipulating TIMAP activity through these compounds, scientists can gain a deeper understanding of the regulatory networks governing cellular responses to external stimuli. This research has implications beyond just the basic science realm, as it may eventually lead to the development of novel strategies for modulating cellular behavior in various contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly elevates intracellular cAMP levels, which can enhance TIMAP activity by activating PKA. PKA can then phosphorylate TIMAP or associated substrates, thereby potentiating TIMAP's role in regulating endothelial barrier function. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA, leading to enhanced phosphorylation of proteins, including TIMAP, which may increase its phosphatase regulatory functions within the cell. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting PP1, Okadaic Acid could indirectly enhance the activity of TIMAP by preventing its dephosphorylation, thereby maintaining its active state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A, like Okadaic Acid, inhibits PP1 and PP2A. Inhibition of PP1 can maintain TIMAP in a phosphorylated, and thus active, state by preventing TIMAP dephosphorylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates intracellular Ca2+ levels by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), which can lead to the activation of Ca2+-dependent signaling pathways, potentially enhancing TIMAP's regulatory functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that can enhance TIMAP activity by promoting phosphorylation events within the cell that might include TIMAP or its associated partners, thereby influencing its role in cell signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, activating Ca2+-dependent protein kinases, which could indirectly enhance TIMAP activity by promoting its phosphorylation state. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is another cell-permeable analog of cAMP that activates PKA and could enhance TIMAP activity by phosphorylation, thus affecting its role in the regulation of the actin cytoskeleton in endothelial cells. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, potentially leading to the activation of TIMAP through Ca2+-dependent signaling pathways that affect endothelial cell function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that could paradoxically lead to the selective activation of TIMAP by altering the balance of kinase and phosphatase activities within the cell. | ||||||