Date published: 2025-10-19

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Thiol-Reactive

Santa Cruz Biotechnology now offers a broad range of Thiol-reactive compounds for use in various applications. Thiol-reactive chemicals are critical tools in biochemistry and molecular biology, primarily used for selectively modifying cysteine residues in proteins and peptides. This capability is essential for studying protein structure, function, and dynamics. These compounds enable researchers to tag proteins with fluorescent markers or other biochemical probes, facilitating the observation of protein interactions, localization, and trafficking within cells. Beyond protein research, thiol-reactive agents are utilized in creating biosensors and developing targeted drug delivery systems, where the precision of thiol-based reactions ensures the correct attachment of agents to specific molecular targets. In materials science, thiol-reactive chemicals are employed to engineer surfaces with specific properties, such as increased biocompatibility or enhanced catalytic activity. Their high reactivity and specificity make them invaluable for crafting molecular assemblies and nanostructures that are fundamental in the development of nanotechnology and biotechnology applications. The unique properties of thiol groups, including their redox-reactivity and ability to form disulfide bonds, also make thiol-reactive compounds ideal for designing dynamic materials that can respond to environmental stimuli. This adaptability has wide-ranging implications for research in environmental science, where they are used to detect and neutralize toxic substances. View detailed information on our available Thiol-reactive compounds by clicking on the product name.

Items 31 to 40 of 61 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cyanine 3 Bihexanoic Acid Dye, Potassium Salt

762260-71-9sc-358103
500 µg
$380.00
(0)

Cyanine 3 Bihexanoic Acid Dye, Potassium Salt exhibits unique reactivity with thiols through its electrophilic sites, enabling efficient conjugation and the formation of robust thioether bonds. Its extended conjugated system enhances fluorescence, allowing for sensitive detection in various environments. The dye's hydrophobic bihexanoic acid tail promotes membrane permeability, while its ionic nature ensures solubility in aqueous solutions, facilitating diverse interactions in biochemical assays.

ThioFluor 623

1004324-99-5sc-205524
sc-205524A
5 mg
10 mg
$350.00
$600.00
(0)

ThioFluor 623 is a thiol compound characterized by its strong nucleophilic properties, which facilitate rapid reactions with electrophiles. Its unique structure allows for selective binding to metal ions, enhancing its role in catalysis and material science. The compound exhibits notable stability under varying pH conditions, making it suitable for diverse chemical environments. Additionally, its ability to form stable adducts with various substrates highlights its versatility in synthetic pathways.

t-Boc-MTSEA-Fluorescein

1042688-20-9sc-207818
10 mg
$360.00
(0)

t-Boc-MTSEA-Fluorescein is a thiol-reactive compound distinguished by its ability to form covalent bonds with thiol groups, enabling precise labeling and tracking of biomolecules. Its unique fluorescein moiety provides strong fluorescence, facilitating real-time monitoring in complex systems. The compound exhibits selective reactivity, allowing for targeted modifications in diverse chemical environments, and its stability under various conditions enhances its utility in biochemical applications.

Cyanine 3 Monofunctional MTSEA Dye, Potassium Salt

sc-358106
500 µg
$427.00
(0)

Cyanine 3 Monofunctional MTSEA Dye, Potassium Salt is a thiol-reactive dye characterized by its robust interaction with thiol groups, leading to the formation of stable thioether linkages. This compound features a unique cyanine backbone that imparts exceptional photostability and high molar absorptivity, making it suitable for sensitive detection. Its distinct reaction kinetics allow for rapid conjugation, enabling efficient labeling in diverse biochemical contexts while maintaining structural integrity.

CruzQuench™ 1 maleimide

sc-362629
5 mg
$244.00
(0)

CruzQuench™ 1 maleimide is a specialized thiol-reactive compound known for its selective reactivity with thiol groups, facilitating the formation of covalent bonds. Its unique structure enhances the efficiency of conjugation reactions, promoting rapid and specific labeling. The compound exhibits remarkable stability under various conditions, ensuring reliable performance in diverse applications. Its distinct molecular interactions contribute to its effectiveness in forming stable adducts, making it a valuable tool in biochemical research.

Tetramethylrhodamine-6-maleimide

174568-68-4sc-215962
5 mg
$900.00
(0)

Tetramethylrhodamine-6-maleimide is a highly reactive thiol-specific probe that exhibits exceptional fluorescence properties, enabling sensitive detection in biochemical assays. Its maleimide moiety selectively targets thiol groups, facilitating rapid conjugation and forming stable thioether linkages. The compound's unique electronic structure enhances its photostability and brightness, making it ideal for real-time monitoring of molecular interactions. Its distinct reactivity profile allows for versatile applications in labeling and tracking biomolecules.

6-Bromoacetyl-2-dimethylaminonaphthalene

210832-86-3sc-210484A
sc-210484B
sc-210484
sc-210484C
1 mg
5 mg
10 mg
25 mg
$153.00
$285.00
$398.00
$745.00
4
(0)

6-Bromoacetyl-2-dimethylaminonaphthalene is a potent electrophile that engages thiol groups through nucleophilic substitution, forming stable thioether bonds. Its unique naphthalene structure contributes to significant π-π stacking interactions, enhancing its reactivity and selectivity. The compound's electron-withdrawing bromoacetyl group increases electrophilicity, facilitating rapid reaction kinetics with thiols. This specificity allows for precise modifications in various chemical environments, making it a valuable tool in synthetic chemistry.

Bodipy Methanethiosulfonate

sc-217783
5 mg
$342.00
(0)

Bodipy Methanethiosulfonate is a highly reactive compound characterized by its ability to form covalent bonds with thiol groups via a Michael addition mechanism. The presence of the Bodipy moiety imparts strong fluorescence properties, enabling real-time monitoring of reaction dynamics. Its unique sulfonate group enhances solubility in aqueous environments, promoting efficient interactions with thiols. This compound's distinct electronic properties facilitate selective labeling and tracking in complex biochemical systems.

Neo-Cyanine 3

427882-81-3sc-219343
2.5 mg
$380.00
(0)

Neo-Cyanine 3 is a versatile thiol-reactive compound known for its unique ability to engage in nucleophilic substitution reactions with thiol groups. Its distinct chromophore structure allows for significant shifts in electronic properties, enhancing its reactivity. The compound exhibits rapid reaction kinetics, making it suitable for dynamic studies. Additionally, its hydrophobic characteristics influence partitioning behavior in mixed environments, affecting interaction profiles with biomolecules.

Neo-Cyanine 3 Methanethiosulfonate

sc-219344
1 mg
$490.00
(0)

Neo-Cyanine 3 Methanethiosulfonate is a specialized thiol-reactive agent characterized by its unique sulfonate moiety, which enhances its electrophilic nature. This compound demonstrates a propensity for forming stable thioether linkages through selective reactions with thiol groups. Its distinct electronic configuration contributes to notable fluorescence properties, allowing for effective monitoring of reaction progress. Furthermore, its solubility profile facilitates interactions in diverse chemical environments, influencing its reactivity and stability.