Date published: 2025-10-19

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Thiol-Reactive

Santa Cruz Biotechnology now offers a broad range of Thiol-reactive compounds for use in various applications. Thiol-reactive chemicals are critical tools in biochemistry and molecular biology, primarily used for selectively modifying cysteine residues in proteins and peptides. This capability is essential for studying protein structure, function, and dynamics. These compounds enable researchers to tag proteins with fluorescent markers or other biochemical probes, facilitating the observation of protein interactions, localization, and trafficking within cells. Beyond protein research, thiol-reactive agents are utilized in creating biosensors and developing targeted drug delivery systems, where the precision of thiol-based reactions ensures the correct attachment of agents to specific molecular targets. In materials science, thiol-reactive chemicals are employed to engineer surfaces with specific properties, such as increased biocompatibility or enhanced catalytic activity. Their high reactivity and specificity make them invaluable for crafting molecular assemblies and nanostructures that are fundamental in the development of nanotechnology and biotechnology applications. The unique properties of thiol groups, including their redox-reactivity and ability to form disulfide bonds, also make thiol-reactive compounds ideal for designing dynamic materials that can respond to environmental stimuli. This adaptability has wide-ranging implications for research in environmental science, where they are used to detect and neutralize toxic substances. View detailed information on our available Thiol-reactive compounds by clicking on the product name.

Items 51 to 60 of 61 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DNP maleimide

62024-74-2sc-397334
25 mg
$255.00
(0)

DNP maleimide is a versatile compound characterized by its strong reactivity towards thiol groups, enabling selective conjugation. The maleimide functionality promotes rapid Michael addition reactions, resulting in stable thioether linkages. Its unique electronic structure enhances the rate of reaction, making it an efficient choice for labeling and tracking thiol-containing biomolecules. Additionally, the compound's hydrophobic nature influences its interaction dynamics in complex biological systems, providing insights into thiol-mediated processes.

2-Hydroxy-5-nitrobenzyl bromide

772-33-8sc-251767
5 g
$26.00
(0)

2-Hydroxy-5-nitrobenzyl bromide exhibits notable reactivity with thiol groups, facilitating nucleophilic substitution reactions. The presence of the nitro group enhances electrophilicity, promoting rapid thiol addition and subsequent bond formation. This compound's unique steric and electronic properties allow for selective targeting of thiols, leading to distinct reaction pathways. Its solubility characteristics further influence its interaction with various substrates, making it a compelling choice for studying thiol reactivity in diverse chemical environments.

3-(2-Pyridyldithio)propanoic Acid Hydrazide

115616-51-8sc-209452
5 mg
$360.00
(0)

3-(2-Pyridyldithio)propanoic Acid Hydrazide is characterized by its ability to form stable thiol adducts through its pyridyl disulfide moiety, which enhances its reactivity in redox processes. The compound's hydrazide functionality allows for versatile interactions with nucleophiles, facilitating unique reaction kinetics. Its distinct molecular structure promotes selective binding to thiols, enabling the exploration of thiol-disulfide exchange mechanisms and influencing the stability of resultant complexes in various chemical contexts.

Thiolite™ Blue

sc-477256
5 mg
$119.00
(0)

Thiolite™ Blue exhibits remarkable properties as a thiol, primarily through its ability to engage in selective thiol-disulfide exchange reactions. Its unique molecular architecture allows for enhanced electron donation, facilitating rapid redox cycling. The compound's strong affinity for metal ions leads to the formation of stable coordination complexes, influencing reaction pathways and kinetics. Additionally, its distinct chromophoric characteristics enable effective monitoring of thiol-related processes in diverse chemical environments.

5-(2-Aminoethyl)dithio-2-nitrobenzoic Acid

71899-86-0sc-214299
10 mg
$260.00
(0)

5-(2-Aminoethyl)dithio-2-nitrobenzoic Acid functions as a thiol with notable reactivity due to its dual thiol groups, which promote efficient nucleophilic attacks on electrophiles. Its unique structure enhances intramolecular interactions, leading to distinct conformational dynamics. The compound's ability to form stable thiolates contributes to its role in catalyzing various reactions, while its nitro group can influence electron density, affecting reaction rates and selectivity in complex chemical systems.

[2-(Aminocarbonyl)ethyl] Methanethiosulfonate

351422-28-1sc-208933
25 mg
$360.00
(0)

[2-(Aminocarbonyl)ethyl] Methanethiosulfonate exhibits remarkable reactivity as a thiol, characterized by its ability to form covalent bonds with electrophiles through its thiol group. The presence of the aminocarbonyl moiety enhances its nucleophilicity, facilitating rapid reaction kinetics. This compound can engage in unique molecular interactions, such as hydrogen bonding and dipole-dipole interactions, which can influence its solubility and stability in various environments, making it a versatile participant in chemical transformations.

N-Iodoacetyl-β-(2-naphthyl)-alanine

1219437-29-2sc-219165
10 mg
$340.00
(0)

N-Iodoacetyl-β-(2-naphthyl)-alanine acts as a potent thiol-reactive agent, showcasing a distinctive ability to form stable thioether linkages through its electrophilic iodoacetyl group. The naphthyl moiety contributes to its hydrophobic character, influencing solubility and interaction dynamics in nonpolar environments. Its reactivity is further enhanced by steric factors, allowing for selective targeting of thiol groups in complex biological systems, thus facilitating intricate reaction pathways.

N-[2-(Trimethylammonium)ethyl]maleimide Chloride

69684-10-2sc-218998
10 mg
$305.00
(0)

N-[2-(Trimethylammonium)ethyl]maleimide Chloride exhibits remarkable reactivity towards thiols, primarily through its maleimide moiety, which forms stable thioether bonds. The presence of the trimethylammonium group enhances solubility in aqueous environments, promoting efficient interaction with thiol-containing compounds. This compound's unique charge distribution facilitates rapid reaction kinetics, allowing for selective labeling and modification of biomolecules, thereby enabling diverse biochemical applications.

MTS-Pentyl

sc-218887
sc-218887A
10 mg
100 mg
$280.00
$1600.00
(0)

MTS-Pentyl is a thiol-reactive compound characterized by its ability to form covalent bonds with thiol groups, leading to the creation of stable thioether linkages. Its unique structure promotes specific molecular interactions, enhancing selectivity in reactions. The compound's hydrophobic pentyl chain contributes to its solubility properties, influencing reaction kinetics and facilitating the formation of adducts in various chemical environments. This behavior underscores its potential in diverse synthetic pathways.

MTSET-Chloride

210167-37-6sc-215398
sc-215398A
10 mg
100 mg
$278.00
$2200.00
2
(1)

MTSET-Chloride is a thiol-reactive agent known for its selective reactivity with thiol groups, resulting in the formation of stable thioether bonds. Its unique electrophilic nature allows for rapid reaction kinetics, making it an effective tool for probing protein structure and dynamics. The presence of a chloride moiety enhances its reactivity, facilitating specific interactions in diverse chemical environments, which can lead to tailored modifications in biomolecular studies.