THAP1 Inhibitors
THAP1 is a transcription factor with a specific DNA-binding domain that regulates the expression of target genes. Its role is crucial in processes such as cell cycle regulation and apoptosis. Chemical compounds that can indirectly influence THAP1 activity are those that interfere with DNA binding or alter gene expression. These include DNA intercalators, minor groove binders, and compounds that can cross-link DNA. Additionally, inhibitors of signaling pathways that modulate transcription factor function can also impact the activity of THAP1.
The chemical class that might be considered as indirect THAP1 inhibitors would be composed of a diverse group of agents, including DNA-binding molecules that interfere with the transcription factor's ability to interact with its target DNA sequences, as well as signaling pathway inhibitors that affect the expression, localization, or activity of transcription factors such as THAP1. The influence of these compounds on THAP1 would primarily be through the disruption of its role as a transcription factor, affecting its regulatory influence on gene expression rather than inhibiting its function through direct binding.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
An antineoplastic antibiotic that binds to GC-rich DNA sequences, potentially affecting THAP1-DNA interactions. | ||||||
Chromomycin A3 | 7059-24-7 | sc-200907 | 10 mg | $260.00 | ||
A glycosidic antibiotic that binds to GC-rich sequences and could influence DNA binding of transcription factors like THAP1. | ||||||
Pentamidine | 100-33-4 | sc-208158 sc-208158A | 25 mg 50 mg | $380.00 $568.00 | ||
An antiprotozoal agent that also binds to AT-rich regions of the minor groove of DNA, which might affect THAP1 DNA binding. | ||||||
Quinomycin A | 512-64-1 | sc-202306 | 1 mg | $166.00 | 4 | |
A bisintercalator that binds to DNA at CG-rich sequences, potentially disrupting THAP1-DNA interactions. | ||||||
Proflavine hemisulfate salt | 1811-28-5 | sc-215749 sc-215749A | 10 g 25 g | $37.00 $112.00 | ||
An acridine dye that intercalates into DNA and could potentially interfere with THAP1 DNA binding. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
An antibiotic that intercalates into DNA and prevents RNA synthesis, potentially altering THAP1-mediated gene expression. | ||||||
H-7, Dihydrochloride | 108930-17-2 | sc-24009 sc-24009A | 10 mg 50 mg | $80.00 $319.00 | ||
A protein kinase inhibitor that can affect multiple signaling pathways and potentially modulate the function or expression of transcription factors like THAP1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK) that could influence transcription factor activity, potentially impacting THAP1. | ||||||