Molecular structure of Chromomycin A3, CAS Number: 7059-24-7
Chromomycin A3 (CAS 7059-24-7)
Application:
Chromomycin A3 is a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye
CAS Number:
7059-24-7
Purity:
≥97%
Molecular Weight:
1183.25
Molecular Formula:
C57H82O26
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chromomycin A3, a fluorescent DNA stain and antibiotic, has been reported to strongly inhibit zinc-dependent transcriptional activity of sheep Metallothionein 1A promoter in reporter gene assays of transfected cells. This compound has also been shown to be a potent inhibitor of neuronal apoptosis induced by glutathione depletion-induced oxidative stress and DNA-damaging agent Camptothecin (sc-200871). Mechanistic studies suggest that Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.
Chromomycin A3 (CAS 7059-24-7) References
- Normal sperm morphology and chromatin packaging: comparison between aniline blue and chromomycin A3 staining. | Franken, DR., et al. 1999. Andrologia. 31: 361-6. PMID: 10643511
- Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons. | Chatterjee, S., et al. 2001. Ann Neurol. 49: 345-54. PMID: 11261509
- Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3. | Mir, MA., et al. 2003. Bioorg Med Chem. 11: 2791-801. PMID: 12788353
- Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. | Menéndez, N., et al. 2004. Chem Biol. 11: 21-32. PMID: 15112992
- Use of chromomycin A3 staining in bovine sperm cells for detection of protamine deficiency. | Simões, R., et al. 2009. Biotech Histochem. 84: 79-83. PMID: 19306222
- Evaluation of sperm's chromatin quality with acridine orange test, chromomycin A3 and aniline blue staining in couples with unexplained recurrent abortion. | Kazerooni, T., et al. 2009. J Assist Reprod Genet. 26: 591-6. PMID: 19894107
- Biocatalytic strategies for the asymmetric synthesis of alpha-hydroxy ketones. | Hoyos, P., et al. 2010. Acc Chem Res. 43: 288-99. PMID: 19908854
- Chromomycin A3 staining, sperm chromatin structure assay and hyaluronic acid binding assay as predictors for assisted reproductive outcome. | Nijs, M., et al. 2009. Reprod Biomed Online. 19: 671-84. PMID: 20021715
- NMR studies of chromomycin A3 interaction with DNA. | Berman, E., et al. 1985. Biochemistry. 24: 6887-93. PMID: 2416346
- Mechanism of action of chromomycin A3. II. Inhibition of RNA polymerase reaction. | Kajiro, Y. and Kamiyama, M. 1967. J Biochem. 62: 424-9. PMID: 5587590
- Chromomycin A3 studies in aqueous solutions. Spectrophotometric evidence for aggregation and interaction with herring sperm deoxyribonucleic acid. | Hayasaka, T. and Inoue, Y. 1969. Biochemistry. 8: 2342-7. PMID: 5816376
- Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells. | Wong, SS., et al. 1994. Biochem Pharmacol. 47: 827-37. PMID: 7510966
- Selective accumulation of diamidino yellow and chromomycin A3 by retinal glial cells. | Jeon, CJ. and Masland, RH. 1993. J Histochem Cytochem. 41: 1651-8. PMID: 8409373
Inhibitor of:
BC049762, C8orf70, EG666257, Exportin (XPO), Exportin 5, Exportin 7, FLJ10357, FOXD1, GTF3A, HGSNAT, HMBOX1, HMG-2, HMGI-C, HMGN3, Hop, HTH, Jaz, KRTAP10, KRTAP5, L1TD1, Liprin α3, LOC100041019, LOC643623, LOC647166, LRRC39, POTE15, Psg18, RCBTB1, RFX8, Spag4l, SPIN1, TFIIIC220, THAP1, Tpbpa, TSPAN18, VSTM2L, and ZP3R.Activator of:
Esp1, HMG-1L, and ZNF440.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chromomycin A3, 10 mg | sc-200907 | 10 mg | $260.00 |