TGFα Inhibitors
TGFα inhibitors represent a diverse class of chemicals with the capability to directly or indirectly modulate the signaling pathways associated with TGFα. Chemicals like SB431542, LY364947, and Galunisertib function as direct inhibitors by selectively targeting the TGF-β type I receptor (ALK5), disrupting downstream Smad signaling and inhibiting the transcriptional responses induced by TGFα. These direct inhibitors showcase the specificity of their actions, providing targeted interference with the TGFα signaling cascade. Additionally, indirect inhibitors such as Pirfenidone and Nintedanib influence TGFα activity by targeting the PI3K/Akt and PI3K/Akt/mTOR pathways, respectively. By inhibiting PI3K, these chemicals disrupt the intracellular signaling cascade utilized by TGFα for its cellular manipulations. This interference results in the attenuation of TGFα-mediated effects on cellular processes, offering alternative strategies for inhibiting TGFα through targeted disruption of critical signaling pathways.
Furthermore, compounds like SD-208 and RepSox act as direct inhibitors by specifically targeting TGF-β receptor type I and ALK5, leading to the inhibition of downstream Smad phosphorylation and subsequent attenuation of TGFα-induced transcriptional responses. These chemicals exemplify the multifaceted approaches within the TGFα inhibitors class, demonstrating both direct and indirect modes of interference with TGFα signaling. In summary, TGFα inhibitors comprise a versatile class of chemicals with direct and indirect mechanisms of action, providing targeted interference with TGFα signaling pathways. Understanding the specific biochemical and cellular pathways influenced by these inhibitors offers valuable insights into the complex regulatory networks governing TGFα activity. The diversity within this chemical class presents opportunities for developing novel strategies to modulate TGFα and its associated cellular effects.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542, a selective inhibitor of TGF-β type I receptor (ALK5), serves as a direct inhibitor of TGFα. By targeting ALK5, SB431542 prevents the activation of downstream Smad signaling, inhibiting the transcriptional response induced by TGFα. This inhibition results in the attenuation of TGFα-mediated cellular processes, highlighting SB431542 as a chemical with direct inhibitory effects on TGFα signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $105.00 $153.00 | 4 | |
LY364947, a selective TGF-β type I receptor (ALK5) inhibitor, serves as a direct inhibitor of TGFα by disrupting ALK5-mediated signaling. Through inhibition of ALK5, LY364947 blocks downstream Smad phosphorylation, leading to the inhibition of TGFα-induced transcriptional responses. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $209.00 $352.00 | 3 | |
LY2157299, a selective TGF-β type I receptor (ALK5) inhibitor, acts as a direct inhibitor of TGFα signaling. By targeting ALK5, LY2157299 impedes the downstream phosphorylation of Smad proteins, inhibiting the transcriptional response triggered by TGFα. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $86.00 | 3 | |
TGF-β RI Kinase Inhibitor V interferes with the downstream Smad phosphorylation, leading to the inhibition of TGFα-induced transcriptional responses. This direct interference with TGFα signaling attenuates its cellular effects. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $75.00 $150.00 $215.00 $650.00 $1224.00 $4296.00 $7818.00 | 8 | |
ALK5 Inhibitor II serves as a direct inhibitor of TGFα by disrupting ALK5-mediated signaling. Through inhibition of ALK5, RepSox blocks downstream Smad phosphorylation, leading to the inhibition of TGFα-induced transcriptional responses. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
EW-7197, a selective ALK5 kinase inhibitor, serves as a direct inhibitor of TGFα by disrupting ALK5-mediated signaling. Through inhibition of ALK5, EW-7197 blocks downstream Smad phosphorylation, leading to the inhibition of TGFα-induced transcriptional responses. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $321.00 $1350.00 | 2 | |
SB505124, a selective TGF-β type I receptor (ALK4/5) inhibitor, acts as a direct inhibitor of TGFα by disrupting ALK4/5-mediated signaling. Through inhibition of ALK4/5, SB505124 blocks downstream Smad phosphorylation, leading to the inhibition of TGFα-induced transcriptional responses. This direct interference with TGFα signaling results in the attenuation of TGFα-mediated cellular processes, establishing SB505124 as a chemical with direct inhibitory actions on TGFα. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $650.00 | 16 | |
A-83-01, a selective ALK5 inhibitor, serves as a direct inhibitor of TGFα by disrupting ALK5-mediated signaling. Through inhibition of ALK5, A-83-01 blocks downstream Smad phosphorylation, leading to the inhibition of TGFα-induced transcriptional responses. This direct interference with TGFα signaling results in the attenuation of TGFα-mediated cellular processes, highlighting A-83-01 as a chemical with direct inhibitory effects on TGFα. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $100.00 $408.00 | 6 | |
Pirfenidone, an anti-fibrotic agent, serves as an indirect inhibitor of TGFα by modulating the PI3K/Akt signaling pathway. By inhibiting PI3K, Pirfenidone disrupts the downstream signaling cascade utilized by TGFα for its cellular manipulations. | ||||||
BIBF1120 | 656247-17-5 | sc-364433 sc-364433A | 5 mg 10 mg | $180.00 $315.00 | 2 | |
BIBF1120, a triple angiokinase inhibitor, acts as an indirect inhibitor of TGFα by targeting the PI3K/Akt/mTOR pathway. Through inhibition of PI3K and mTOR, BIBF1120 disrupts the downstream signaling cascade that TGFα exploits for its cellular manipulations. | ||||||