TEX12 Inhibitors
Chemical inhibitors of TEX12 function by disrupting the microtubule structures upon which this protein depends for its role in the synaptonemal complex during meiosis. Paclitaxel and Peloruside A, for instance, stabilize microtubules, which may sound counterintuitive, but this stabilization actually prevents the dynamic changes in microtubule structure that are necessary for proper chromosomal pairing and segregation. By locking microtubules in a rigid state, these agents prevent the flexibility required for the synaptonemal complex to operate effectively, thus inhibiting TEX12. On the other end of the spectrum, Colchicine, Nocodazole, Vinblastine, Vincristine, Podophyllotoxin, Eribulin, Griseofulvin, Combretastatin A-4, and 2-Methoxyestradiol all inhibit microtubule polymerization. This leads to the disruption of microtubule formation, which is a critical component of the synaptonemal complex's structure and function. Without properly formed microtubules, the synaptonemal complex cannot maintain its integrity, and TEX12 cannot fulfill its role in facilitating correct chromosomal interactions during meiosis.
Moreover, the precise action of these chemical inhibitors on microtubules varies, but the end result converges on the inhibition of TEX12. Vinblastine and Vincristine bind to tubulin, the building block of microtubules, preventing their proper assembly. This action directly impairs the formation of structures necessary for TEX12's function in meiotic chromosomal organization. In contrast, Podophyllotoxin and Griseofulvin bind at different sites but lead to a similar outcome, hindering the polymerization of tubulin into microtubules and thereby disrupting the necessary cellular framework for the synaptonemal complex. Combretastatin A-4 and 2-Methoxyestradiol also target tubulin and its polymerization process, further illustrating the diverse molecular targets among these chemicals that culminate in the inhibition of TEX12.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and inhibits their disassembly, which is crucial for cell division and proper chromosome segregation. By stabilizing microtubules, paclitaxel can inhibit TEX12, which is essential for the synaptonemal complex formation during meiosis, by preventing the dynamic changes required for chromosomal pairing and separation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization into microtubules, disrupting their formation. Disruption of microtubule formation by colchicine can inhibit TEX12 function by preventing the assembly of the synaptonemal complex, which depends on microtubule structures for chromosome alignment and segregation during meiosis. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that interferes with microtubule dynamics. By depolymerizing microtubules, nocodazole inhibits TEX12 by disrupting the microtubule-dependent formation and maintenance of the synaptonemal complex, which is critical for meiotic chromosomal pairing and segregation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule assembly. By preventing the proper microtubule formation, vinblastine can inhibit TEX12 by disrupting the microtubule-dependent processes necessary for the assembly of the synaptonemal complex and, consequently, meiotic chromosome pairing and segregation. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, leading to microtubule disassembly. This action can functionally inhibit TEX12 by disrupting the microtubule structures required for the synaptonemal complex formation, which is essential for the correct meiotic chromosomal pairing and segregation. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin binds to tubulin and inhibits its polymerization into microtubules. By disrupting the microtubule network, eribulin can inhibit TEX12 function by preventing the assembly of the synaptonemal complex, which is necessary for meiotic chromosome pairing and segregation. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin and inhibiting its polymerization. This can inhibit TEX12 by impairing the proper assembly of the synaptonemal complex, which relies on functional microtubules for meiotic chromosome pairing and segregation. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol binds to tubulin, inhibiting its polymerization into microtubules. This can inhibit TEX12 by disrupting the microtubule-dependent formation of the synaptonemal complex, which is critical for the proper alignment and segregation of chromosomes during meiosis. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts spindle bipolarity by inhibiting the motor protein's ATPase activity. As TEX12 is involved in the synaptonemal complex that requires proper spindle formation for chromosome pairing during meiosis, inhibition of spindle dynamics by monastrol can result in functional | ||||||