TET2 Inhibitors
Common TET2 Inhibitors include, but are not limited to 5-Azacytidine CAS 320-67-2, Parthenolide CAS 20554-84-1, Curcumin CAS 458-37-7, 2,4-Pyridinedicarboxylic acid monohydrate CAS 207671-42-9 and Dimethyloxaloylglycine (DMOG) CAS 89464-63-1.
TET2 inhibitors belong to a chemical class designed to target the activity of the ten-eleven translocation 2 (TET2) enzyme, which plays a crucial role in epigenetic regulation by catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) on DNA. This enzymatic activity is involved in DNA demethylation, a process that contributes to the dynamic regulation of gene expression and cellular identity.
By inhibiting TET2, researchers aim to modulate DNA methylation patterns and epigenetic landscapes, leading to alterations in gene expression profiles and cellular differentiation. TET2 inhibitors hold promise for investigating the intricate connections between epigenetic modifications, gene regulation, and various cellular processes. The study of TET2 inhibitors contributes to advancing our understanding of epigenetic mechanisms and their role in development and cellular plasticity. These inhibitors offer valuable tools for elucidating the complex interplay between epigenetics and cellular physiology, furthering the field's knowledge of epigenetic regulation's implications in various biological contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
A chemical that could potentially inhibit TET2 activity, impacting DNA demethylation and epigenetic regulation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
A natural compound with potential inhibitory effects on TET2 enzymatic activity, potentially impacting DNA demethylation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound that may modulate TET2 expression and activity, potentially affecting DNA demethylation processes. | ||||||
2,4-Pyridinedicarboxylic acid monohydrate | 207671-42-9 | sc-225693 | 1 g | $29.00 | ||
A potential TET2 inhibitor that could affect its enzymatic activity, potentially impacting DNA demethylation. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
An inhibitor of prolyl hydroxylases that might impact TET2 stability and activity, affecting DNA demethylation. | ||||||
1-Benzoyl-3-phenyl-2-thiourea | 4921-82-8 | sc-258614A sc-258614 | 1 g 5 g | $43.00 $129.00 | ||
An inhibitor that could potentially affect TET2 enzymatic activity, influencing DNA demethylation and epigenetic regulation. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
An inhibitor of histone demethylases that could affect TET2 expression and epigenetic regulation. | ||||||