TCP-10b Activators
Chemical activators of TCP-10b can initiate a cascade of intracellular events leading to its activation through various mechanisms that ultimately increase the levels of cyclic AMP (cAMP) within cells. Forskolin, directly targeting adenylyl cyclase, elevates cAMP production, which in turn can activate protein kinase A (PKA). Once activated, PKA can phosphorylate and activate TCP-10b. Similarly, Isoproterenol, L-858051, Salbutamol, Terbutaline, and Dobutamine are beta-adrenergic agonists that bind to their respective receptors, triggering G-protein activation, which then stimulates adenylyl cyclase to increase cAMP levels. This rise in cAMP leads to the activation of PKA, which can phosphorylate and thus activate TCP-10b. Glucagon, by binding to its receptor, also stimulates adenylyl cyclase, further contributing to the cAMP pool and subsequent activation of PKA, potentially leading to the activation of TCP-10b.
PGE1 engages with its G-protein-coupled receptor to stimulate adenylyl cyclase, which increases cAMP and, consequently, PKA activity that can activate TCP-10b. Cholera toxin exerts a sustained activation of the Gs alpha subunit, leading to continuous adenylyl cyclase stimulation and persistent cAMP elevation, which can result in PKA activation and the subsequent activation of TCP-10b. IBMX and Rolipram work by inhibiting phosphodiesterases, thereby preventing cAMP breakdown, which leads to an accumulation of cAMP within cells. This accumulation can enhance PKA activity, which may lead to TCP-10b activation. Epinephrine, interacting with both alpha and beta-adrenergic receptors, leads to increased cAMP production through adenylyl cyclase activation, which can result in PKA-mediated activation of TCP-10b. Through these varied mechanisms, each chemical can contribute to the regulation of TCP-10b activity within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP can then activate cAMP-dependent protein kinase (PKA), which can phosphorylate and thus activate TCP-10b as part of downstream signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, binds to beta-adrenergic receptors, leading to G-protein activation and subsequent adenylyl cyclase activation. This raises intracellular cAMP, which can in turn activate PKA and potentially TCP-10b activation. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
PGE1 binds to its G-protein-coupled receptor, stimulating adenylyl cyclase and increasing cAMP levels. The elevated cAMP activates PKA, which could activate TCP-10b through phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which leads to an increase in cAMP levels by preventing its breakdown. The increase in cAMP can activate PKA, which in turn may lead to the activation of TCP-10b. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels in cells. Higher cAMP levels activate PKA, which may lead to phosphorylation and activation of TCP-10b. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a beta-2 adrenergic agonist that activates adenylyl cyclase via the beta-2 adrenergic receptor, increasing cAMP levels. This can lead to PKA activation, potentially resulting in TCP-10b activation. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline, a beta-2 adrenergic agonist, stimulates adenylyl cyclase through the beta-2 adrenergic receptor, increasing cAMP production. Increased cAMP can activate PKA, which may lead to the activation of TCP-10b. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine, a beta-1 adrenergic agonist, binds to beta-1 adrenergic receptors, leading to an increase in cAMP and activation of PKA. PKA can phosphorylate and activate TCP-10b within the related signaling pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to both alpha and beta-adrenergic receptors, stimulating adenylyl cyclase and increasing cAMP levels. The rise in cAMP activates PKA, which in turn may lead to phosphorylation and activation of TCP-10b. | ||||||