Date published: 2026-3-31

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TCFL5 Inhibitors

TCFL5 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the transcription factor TCFL5 (Transcription Factor Like 5), which plays an important role in regulating gene expression. TCFL5 is involved in the transcriptional regulation of various genes, particularly those linked to cell differentiation, development, and gene silencing. As a transcription factor, TCFL5 binds to specific DNA sequences in the promoter regions of target genes, influencing their transcription into mRNA. By inhibiting TCFL5, these compounds can interfere with its ability to modulate the expression of genes involved in key cellular processes such as development, cell cycle progression, and cellular responses to environmental signals.

The use of TCFL5 inhibitors in research offers a valuable tool for exploring the role of this transcription factor in controlling gene networks that are critical for proper cellular function. By blocking TCFL5 activity, researchers can study the downstream effects on gene expression patterns, gaining insights into the regulatory mechanisms that govern cell differentiation and the maintenance of cellular identity. TCFL5 inhibitors help to elucidate how changes in transcription factor activity can impact cellular development and the coordination of gene expression programs during specific stages of growth and differentiation. This class of inhibitors is also instrumental in dissecting the functional roles of transcription factors in broader gene regulatory networks, providing a clearer understanding of the intricate controls over gene expression and the factors that contribute to the proper functioning of biological systems. Through the study of TCFL5 inhibitors, scientists can advance their knowledge of transcriptional regulation and its importance in various aspects of cellular biology.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

This compound inhibits eukaryotic protein synthesis, potentially reducing TCFL5 levels by preventing its translation.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide inhibits transcriptional activity by affecting RNA polymerase II, which could downregulate TCFL5 expression.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

It binds to DNA and halts RNA synthesis, which could decrease TCFL5 transcription.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

This toxin inhibits RNA polymerase II, potentially leading to reduced transcription of TCFL5.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

It binds to GC-rich DNA sequences, possibly inhibiting the transcription of TCFL5 if its promoter is GC-rich.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, which can lead to a reduction in protein synthesis, including that of TCFL5.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This compound incorporates into DNA, demethylating it and potentially affecting TCFL5 gene expression.

Lomeguatrib

192441-08-0sc-362764
sc-362764A
10 mg
50 mg
$205.00
$865.00
(0)

Chetomin disrupts the chromatin environment, possibly leading to the downregulation of TCFL5 expression.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

As a proteasome inhibitor, it can cause the accumulation of misfolded proteins, indirectly reducing TCFL5 levels.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

JQ1 inhibits the BET family of bromodomain proteins, potentially decreasing transcription of TCFL5.