TBG Activators
TBG activators are a class of compounds that enhance the functional activity of TBG by increasing the availability of thyroid hormones, which are substrates for TBG, or by increasing the levels of TBG in the blood. The list of TBG activators includes hormones like Thyrotropin-releasing hormone (TRH), and synthetic thyroid hormones such as Levothyroxine and Liothyronine. TRH stimulates the anterior pituitary gland to release thyroid-stimulating hormone (TSH), which then prompts the thyroid gland to release thyroxine (T4), a major substrate of TBG. Increased T4 levels lead to higher binding with TBG, thereby enhancing its functional activity. On the other hand, Levothyroxine and Liothyronine, being synthetic forms of T4 and triiodothyronine (T3) respectively, increase the levels of these hormones in the body, thus providing more substrate for TBG and enhancing its functional activity.
Other TBG activators include compounds like Iodine and Potassium iodide, which are essential for the synthesis of thyroid hormones, and drugs like Propylthiouraciland Methimazole, which are used to suppress the overproduction of thyroid hormones, maintaining a balanced hormone level for TBG binding. Selenium, provided by Selenomethionine, is a trace element required for proper thyroid function and hormone production, thereby indirectly enhancing TBG activity. Propranolol, as a beta-blocker, inhibits the conversion of T4 to T3, leading to an increase in T4 levels, which can enhance TBG activity. The drug Amiodarone, due to its high iodine content, can enhance the production of T4, providing more substrate for TBG. Lastly, the progestin Medroxyprogesterone acetate and estrogen (estradiol) can increase TBG levels in the blood, leading to enhanced TBG functionality due to increased availability for hormone binding. Each of these compounds enhances TBG activity through unique and specific biochemical or cellular pathways, either by influencing the production, availability, or conversion of thyroid hormones, or by increasing the concentration of TBG itself.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $40.00 $75.00 $150.00 | ||
Liothyronine is a synthetic form of triiodothyronine (T3), another major thyroid hormone. Like T4, T3 can bind with TBG, and its introduction into the body can enhance TBG's functional activity. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $36.00 $55.00 $220.00 $1958.00 | ||
Propylthiouracil is a drug used to decrease the production of thyroid hormones in cases of hyperthyroidism. By suppressing excess thyroid hormone production, it helps maintain a balance, ensuring adequate hormone availability for TBG binding and function. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole is another drug used to treat hyperthyroidism. It works similarly to Propylthiouracil, reducing excessive thyroid hormone production and ensuring a balanced level of hormones for TBG to bind, thereby enhancing its functional activity. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-blocker that can inhibit the conversion of T4 to T3 in peripheral tissues. This results in an increase in T4 levels, providing more substrate for TBG, thereby enhancing its functional activity. | ||||||
L-Selenomethionine | 3211-76-5 | sc-204050 sc-204050A | 250 mg 1 g | $219.00 $585.00 | 1 | |
Selenomethionine is a source of selenium, a trace element required for the proper function of the thyroid gland and the production of thyroid hormones. This can increase the production of T4, providing more substrate for TBG and enhancing its activity. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $312.00 | ||
Amiodarone is a drug with a high iodine content, which can enhance the production of T4 in the body, providing more substrate for TBG and enhancing its activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estrogen, particularly estradiol, can increase the level of TBG in the blood. This increase allows for more TBG to be available for thyroid hormone binding, enhancing its functional activity. | ||||||