Tachykinins

Substance P is a neuropeptide belonging to the tachykinin family, characterized by its role in neurotransmission and inflammatory responses. It interacts with neurokinin receptors, triggering intracellular signaling cascades that modulate pain perception and stress responses. Its unique sequence of amino acids allows for specific binding affinities, influencing synaptic plasticity. Additionally, Substance P's stability in physiological conditions enhances its biological activity, making it a key player in neurogenic inflammation.

Neurokinin A is a neuropeptide within the tachykinin family, known for its involvement in various physiological processes. It exhibits a high affinity for neurokinin receptors, particularly NK-2, facilitating diverse signaling pathways that influence smooth muscle contraction and neurogenic inflammation. Its distinct amino acid composition contributes to its receptor selectivity and biological potency. Neurokinin A's rapid degradation in the bloodstream underscores its transient yet impactful role in cellular communication and modulation of physiological responses.

Senktide is a synthetic peptide that mimics the action of tachykinins, specifically targeting neurokinin-3 receptors. Its unique structure allows for selective binding, triggering intracellular signaling cascades that modulate neuronal excitability and synaptic transmission. Senktide's interactions with receptor subtypes can lead to varied physiological effects, highlighting its role in neurogenic processes. The peptide's stability and resistance to enzymatic degradation enhance its functional longevity in biological systems.

[Sar-9, Met(O2)-11]-Substance P is a modified tachykinin peptide that exhibits enhanced affinity for neurokinin receptors, particularly neurokinin-1. Its structural modifications facilitate unique conformational dynamics, promoting specific receptor interactions that activate downstream signaling pathways. This peptide's resistance to proteolytic enzymes contributes to its prolonged activity, influencing neurogenic inflammation and pain pathways. Its distinct molecular interactions underscore its role in modulating complex physiological responses.

MEN10376 is a synthetic tachykinin analog characterized by its selective binding to neurokinin receptors, particularly neurokinin-2. Its unique amino acid substitutions enhance receptor activation, leading to distinct signaling cascades. The compound exhibits a remarkable stability against enzymatic degradation, allowing for sustained biological effects. Additionally, MEN10376's conformational flexibility enables it to engage in specific molecular interactions, influencing various cellular processes and contributing to its functional diversity.

Eledoisin is a naturally occurring tachykinin known for its potent affinity for neurokinin receptors, particularly neurokinin-1. Its unique structure facilitates specific interactions with receptor sites, triggering diverse intracellular signaling pathways. Eledoisin's rapid kinetics of receptor binding and subsequent activation lead to swift physiological responses. Furthermore, its ability to form stable complexes with membrane proteins enhances its biological efficacy, influencing various cellular mechanisms.

Neuromedin B is a tachykinin that exhibits a strong affinity for neurokinin receptors, particularly neurokinin-2. Its distinctive peptide sequence allows for selective binding, initiating a cascade of intracellular signaling events. Neuromedin B is characterized by its rapid dissociation kinetics from receptor sites, which contributes to transient physiological effects. Additionally, its interactions with lipid membranes can modulate receptor accessibility, influencing downstream cellular responses.