Senktide CAS: 106128-89-6
MF: C40H55N7O11S
MW: 841.97
A tachykinin NK-3 receptor agonist.

Senktide (CAS 106128-89-6)

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Application: A tachykinin NK-3 receptor agonist
CAS Number: 106128-89-6
Purity: ≥95%
Molecular Weight: 841.97
Molecular Formula: C40H55N7O11S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models. NK-3R (tachykinin NK-3 receptors) have been noted to mediate bronchoconstriction in guinea pig lungs, and activation of these receptors by Senktide has also been shown to induce bronchoconstriction. Furthermore, this agent has demonstrated the ability to induce increased numbers of Fos-LI neurons in numerous regions of the guinea pig brain.


1. Laufer, R., et al. 1986. J. Biol. Chem. 261: 10257-10263. PMID: 2426259
2. Stoessl, A.J., et al. 1987. Neurosci. Lett. 80: 321-326. PMID: 2446214
3. Dam, T.V., et al. 1990. Brain Res. 506: 175-179. PMID: 1689199
4. Corboz, M.R., et al. 2010. Exp. Lung Res. 36: 509-521. PMID: 20939761

Physical State :
Sequence :
Solubility :
Soluble in methanol (25 mg/ml), ethanol (25 mg/ml), and DMSO (25 mg/ml).
Storage :
Store at -20° C
Boiling Point :
1262.64° C at 760 mmHg
Density :
1.29 g/cm3
Refractive Index :
n20D 1.58
IC50 :
Tachykinin receptor 3: EC5050 = 0.5 nM (rat); NK3 receptor: EC5050 = 3 nM (human); NK3 receptor: IC50 = 0.02 µM (human); achykinin receptor 3: IC50 = 0.01 µM (guinea pig)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CCSC)C(=O)N)NC(=O)CNC(=O)[[email protected]](CC1=CC=CC=C1)N(C)C(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(=O)O)NC(=O)CCC(=O)O

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Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Senktide, sc-201174, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-03-28
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