Molecular structure of Senktide, CAS Number: 106128-89-6
Senktide (CAS 106128-89-6)
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Application:
Senktide is a tachykinin NK-3 receptor agonist
CAS Number:
106128-89-6
Purity:
≥95%
Molecular Weight:
841.97
Molecular Formula:
C40H55N7O11S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Senktide selectively interacts with a tachykinin receptor subtype (SP-N) and is in studies to find out the regulation, distribution, and functional role of this receptor. Senktide is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models. NK-3R (tachykinin NK-3 receptors) have been used to mediate bronchoconstriction in guinea pig lungs, and activation of these receptors by Senktide has been to induce bronchoconstriction. This agent has the ability to induce increased numbers of Fos-LI neurons in numerous regions of the guinea pig brain.
Senktide (CAS 106128-89-6) References
- Distribution of Fos-like immunoreactivity within the rat brain following intraventricular injection of the selective NK(3) receptor agonist senktide. | Smith, ME. and Flynn, FW. 2000. J Comp Neurol. 426: 413-28. PMID: 10992247
- Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus. | Sandoval-Guzmán, T. and Rance, NE. 2004. Brain Res. 1026: 307-12. PMID: 15488494
- Interaction of the tachykinin NK3 receptor agonist senktide with behavioral effects of cocaine in marmosets (Callithrix penicillata). | de Souza Silva, MA., et al. 2006. Peptides. 27: 2214-23. PMID: 16621146
- Visualization of neurokinin-3 receptor sites in rat brain using the highly selective ligand [3H]senktide. | Dam, TV., et al. 1990. Brain Res. 506: 175-9. PMID: 1689199
- Intra-midbrain raphe injections of the neurokinin-3 agonist senktide inhibit food and water intake in the rat. | Paris, JM., et al. 1991. Pharmacol Biochem Behav. 38: 223-6. PMID: 1708148
- Senktide-induced gerbil foot tapping behaviour is blocked by selective tachykinin NK1 and NK3 receptor antagonists. | Sundqvist, M., et al. 2007. Eur J Pharmacol. 577: 78-86. PMID: 17920583
- The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. | Nordquist, RE., et al. 2008. Eur J Pharmacol. 600: 87-92. PMID: 18930726
- Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats. | Bassi, GS., et al. 2009. Psychopharmacology (Berl). 204: 13-24. PMID: 19093101
- Bronchoconstrictor effect of the tachykinin NK₃-receptor agonists [MePhe⁷]-neurokinin B and senktide in the isolated guinea pig lung. | Corboz, MR., et al. 2010. Exp Lung Res. 36: 509-21. PMID: 20939761
- Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand. | Laufer, R., et al. 1986. J Biol Chem. 261: 10257-63. PMID: 2426259
- Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. | Stoessl, AJ., et al. 1987. Neurosci Lett. 80: 321-6. PMID: 2446214
- The NK-3 tachykinin receptor agonist senktide elicits 5-HT-mediated behaviour following central or peripheral administration in mice and rats. | Stoessl, AJ., et al. 1988. Br J Pharmacol. 94: 285-7. PMID: 2456111
- A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide. | Krull, AA., et al. 2017. Endocrinology. 158: 3259-3268. PMID: 28531316
- Central administration of senktide, a tachykinin NK-3 agonist, has an antidiuretic action by stimulating AVP release in water-loaded rats. | Saigo, A., et al. 1993. Neurosci Lett. 159: 187-90. PMID: 7505413
- Localization of Fos-like immunoreactivity induced by the NK3 tachykinin receptor agonist, senktide, in the guinea-pig brain. | Yip, J. and Chahl, LA. 1997. Br J Pharmacol. 122: 715-25. PMID: 9375969
Activator of:
NK-3R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Senktide, 1 mg | sc-201174 | 1 mg | $138.00 | |||
Senktide, 5 mg | sc-201174A | 5 mg | $548.00 |