Eledoisin (CAS 69-25-0)

Eledoisin is a neuropeptide from the tachykinin family, originally extracted from the salivary glands of Mediterranean mollusks, and is known for its potent bioactivity which includes vasodilation and smooth muscle contraction. Structurally, it is an 11-amino acid peptide that primarily targets the neurokinin 1 (NK1) receptors, a subgroup of G-protein-coupled receptors. Upon binding to these receptors, eledoisin activates intracellular signaling cascades, notably involving phospholipase C, which subsequently increases intracellular calcium levels, thereby inducing physiological responses such as muscle contractions and vasodilation. In research contexts, eledoisin has been extensively utilized to explore the detailed mechanisms of tachykinin receptor interactions and their physiological consequences. By employing eledoisin in experimental models, scientists have been able to dissect the signaling pathways and functional roles of NK1 receptors in various tissues, contributing significantly to our understanding of neurochemical and smooth muscle regulation. This peptide has also facilitated comparative studies on peptide signaling across different species, providing insights into the evolutionary aspects of neurochemical communication, thereby enriching our knowledge of neurobiology and physiology without delving into its therapeutic potentials.