Date published: 2026-3-17
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[Sar-9, Met(O<sub>2</sub>)-11]-Substance P (CAS 110880-55-2) - chemical structure image
Molecular structure of [Sar-9, Met(O2)-11]-Substance P, CAS Number: 110880-55-2
[Sar-9, Met(O2)-11]-Substance P (CAS 110880-55-2) - chemical structure image
Molecular structure of [Sar-9, Met(O2)-11]-Substance P, CAS Number: 110880-55-2
Molecular structure of [Sar-9, Met(O2)-11]-Substance P, CAS Number: 110880-55-2

[Sar-9, Met(O2)-11]-Substance P (CAS 110880-55-2)

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Application:
[Sar-9, Met(O2)-11]-Substance P is a selective NK1 receptor agonist
CAS Number:
110880-55-2
Purity:
≥97%
Molecular Weight:
1393.7
Molecular Formula:
C64H100N18O15S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Technical Information
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SDS & Certificate of Analysis

[Sar-9, Met(O2)-11]-Substance P is a highly selective NK-1R (NK-1 neurokinin receptor) agonist which stimulates endocytosis of NK-1 receptors but has minimal effect on NK-3 receptors. Studies suggest that this peptide does not insert into neutral or negatively charged lipid bilayers and densely packed lipid monolayers at surface pressures greater than 31 mN/m. Furthermore, in vitro tests show that [Sar-9, Met(O2)-11]-Substance P augments the release of vasopressin from the hypothalamo-neurohypophysial system.


[Sar-9, Met(O2)-11]-Substance P (CAS 110880-55-2) References

  1. Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.  |  Yip, J. and Chahl, LA. 1999. Neuroscience. 94: 663-73. PMID: 10579226
  2. Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.  |  Evans, CM., et al. 2000. Am J Physiol Lung Cell Mol Physiol. 279: L477-86. PMID: 10956622
  3. Independent endocytosis of the NK(1) and NK(3) tachykinin receptors in neurons of the rat myenteric plexus.  |  Jenkinson, KM., et al. 2000. Neuroscience. 100: 191-9. PMID: 10996469
  4. Differential role of neurokinin receptors in human lymphocyte and monocyte chemotaxis.  |  Hood, VC., et al. 2000. Regul Pept. 96: 17-21. PMID: 11102647
  5. Interaction of a substance P agonist and of substance P antagonists with lipid membranes. A thermodynamic analysis.  |  Seelig, A. 1992. Biochemistry. 31: 2897-904. PMID: 1372515
  6. Characteristics of substance P transport across the blood-brain barrier.  |  Chappa, AK., et al. 2006. Pharm Res. 23: 1201-8. PMID: 16729222
  7. Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea.  |  Fong, AY. and Potts, JT. 2006. J Physiol. 575: 869-85. PMID: 16825299
  8. Binding characteristics of [125I]Bolton-Hunter [Sar9,Met(O2)11]substance P, a new selective radioligand for the NK1 receptor.  |  Lew, R., et al. 1990. Eur J Pharmacol. 184: 97-108. PMID: 1698645
  9. 125I-BH[Sar9, Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system.  |  Tousignant, C., et al. 1990. Brain Res. 524: 263-70. PMID: 1705465
  10. Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies.  |  Juszczak, M., et al. 2007. J Physiol Pharmacol. 58: 829-43. PMID: 18195491
  11. Effect of tachykinins on the need-free sodium intake of female rats: a continuous intracerebroventricular infusion study.  |  Polidori, C., et al. 1994. Physiol Behav. 56: 877-82. PMID: 7529926
  12. Characterization and autoradiographic localization of tachykinin receptors in rat gastric fundus.  |  Mussap, CJ. and Burcher, E. 1993. J Pharmacol Exp Ther. 266: 1043-53. PMID: 8394903
  13. Comparative behavioural profile of centrally administered tachykinin NK1, NK2 and NK3 receptor agonists in the guinea-pig.  |  Piot, O., et al. 1995. Br J Pharmacol. 116: 2496-502. PMID: 8581290

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

[Sar-9, Met(O2)-11]-Substance P, 1 mg

sc-201170
1 mg
$130.00
1-800-457-3801
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