Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. In addition, Substance P is essential in smooth muscle contraction, pain, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells. Alternate studies suggest that Substance P is a key factor in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R.
1. V Euler, U.S. and Gaddum, J.H. 1931. J. Physiol. 72: 74-87. PMID: 16994201 2. Mayordomo, C., et al. 2011. J Cell Physiol. PMID: 21604273 3. Komatsu, T., et al. 2011. Neuropharmacology. [Epub ahead of print]. PMID: 21601581
Solubilize the product in an aqueous buffer or DMSO, then run the solution through a sterile filter to achieve a sterile end product.
Soluble in water (1 mg/ml), DMSO, and 5% Acetic Acid.
Rated 5 out of
Komatsu et alKomatsu et al. (PubMed ID 21601581) found that Substance P inhibited the phosphorylation of ERK and reduced nociceptive response resulting from capsaicin induction. -SCBT Publication Review -SCBT Publication Review
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