Substance P (CAS 33507-63-0)
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Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. Alternate studies suggest that Substance P can induce apoptosis and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R. BRD 7389 has also been studied for its potential as a research tool for investigating the functions of BRD4 in cells and model organisms. Because BRD 7389 specifically targets BRD4, it can be used to study the effects of BRD4 inhibition on various cellular processes, such as gene expression, cell cycle regulation, and DNA damage repair.
Substance P (CAS 33507-63-0) References
- Potential of substance P antagonists as antiemetics. | Diemunsch, P. and Grélot, L. 2000. Drugs. 60: 533-46. PMID: 11030465
- The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog. | AMIN, AH., et al. 1954. J Physiol. 126: 596-618. PMID: 13222357
- Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. | Fehrenbacher, JC., et al. 2003. Pain. 105: 133-41. PMID: 14499429
- Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. | Koon, HW., et al. 2004. J Biol Chem. 279: 45519-27. PMID: 15319441
- Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80. | Mousli, M., et al. 1990. FEBS Lett. 259: 260-2. PMID: 1688415
- An unidentified depressor substance in certain tissue extracts. | V Euler, US. and Gaddum, JH. 1931. J Physiol. 72: 74-87. PMID: 16994201
- Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response. | Komatsu, T., et al. 2011. Neuropharmacology. 61: 608-13. PMID: 21601581
- Targeting of substance P induces cancer cell death and decreases the steady state of EGFR and Her2. | Mayordomo, C., et al. 2012. J Cell Physiol. 227: 1358-66. PMID: 21604273
- Substance P primes human neutrophil activation: a mechanism for neurological regulation of inflammation. | Perianin, A., et al. 1989. Biochem Biophys Res Commun. 161: 520-4. PMID: 2472137
- Activation of rat peritoneal mast cells by substance P and mastoparan. | Mousli, M., et al. 1989. J Pharmacol Exp Ther. 250: 329-35. PMID: 2473189
- Activation of microglia by histamine and substance P. | Zhu, J., et al. 2014. Cell Physiol Biochem. 34: 768-80. PMID: 25170632
- Neuropeptide substance P and the immune response. | Mashaghi, A., et al. 2016. Cell Mol Life Sci. 73: 4249-4264. PMID: 27314883
- Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. | Mantyh, CR., et al. 1996. Gastroenterology. 111: 1272-80. PMID: 8898641
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Substance P, 1 mg | sc-201169 | 1 mg | $55.00 |