TACC3 Activators
TACC3 activators, as identified here, are primarily chemicals that influence microtubule dynamics and spindle assembly processes in cells. These activators do not bind directly to TACC3 but impact the cellular environment and pathways crucial for TACC3's function. The primary mode of action of these activators involves either stabilization or disruption of microtubules, which are essential components of the mitotic spindle, a structure where TACC3 plays a significant role.
The chemicals listed, such as Paclitaxel, Taxol, and Docetaxel, are known for their ability to stabilize microtubules, thus potentially enhancing the function of TACC3 in spindle assembly and maintenance. On the other hand, agents like Nocodazole, Colchicine, and Vinblastine act by disrupting microtubule dynamics, leading to altered spindle assembly processes, which can indirectly affect TACC3's activity. These activators are significant in research focused on understanding the cell cycle, particularly mitosis, and the role of TACC3 in these processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, indirectly influencing TACC3 activity by altering the cellular environment essential for its function in spindle assembly. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule dynamics, which can indirectly influence TACC3's role in microtubule stabilization and spindle assembly. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine inhibits microtubule formation, which may indirectly alter TACC3 function by impacting microtubule dynamics in the cell. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization and can indirectly affect TACC3 by altering microtubule dynamics in the cell. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits microtubule growth, indirectly affecting TACC3's function in spindle formation and stability. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Docetaxel, a taxane like Paclitaxel, stabilizes microtubules, potentially influencing TACC3's involvement in microtubule dynamics and spindle assembly. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin inhibitor which can alter microtubule dynamics, indirectly affecting TACC3 activity in spindle assembly. | ||||||