T2R4 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $31.00 $46.00 $138.00 $464.00 $903.00 | ||
Denatonium Benzoate is known as the most bitter compound and acts as a potent T2R4 agonist. By binding to T2R4, it activates the bitter taste receptor pathway, leading to an inhibition of the G-protein coupled signaling cascade that T2R4 is involved in. This results in a decreased functional activity of T2R4. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is an alkaloid that can act as a bitter tastant. It can bind to T2R4 causing activation of the receptor and leading to its desensitization or internalization, thereby reducing the receptor's surface expression and functional activity. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $44.00 $99.00 | 7 | |
Naringin, a flavonoid in grapefruit juice, imparts bitterness and has been shown to interact with T2R4. By stimulating the receptor, naringin can lead to receptor desensitization, reducing T2R4's responsiveness to further stimulation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine is a poisonous alkaloid and secondary metabolite that can modulate multiple cellular processes, including those involved in the inflammatory response. While not a direct inhibitor, it could theoretically affect T2R4 functionality by altering the cellular environment in which T2R4 operates, particularly in the context of inflammation. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin is an antibiotic that has been found to bitter and can bind to T2R4. This binding may result in receptor activation leading to a negative feedback mechanism that diminishes T2R4 activity through desensitization or reduction of receptor density on the cell surface. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is a sesquiterpene lactone from feverfew with known anti-inflammatory properties. It could potentially inhibit T2R4 by modulating the inflammatory pathways in which T2R4 is implicated, thereby indirectly decreasing its activation and functional response. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a bitter compound that can stimulate T2R4. Chronic exposure to caffeine could lead to T2R4 desensitization or downregulation, thereby impairing the receptor's functional activity. | ||||||
D-(−)-Salicin | 138-52-3 | sc-218004 | 5 g | $58.00 | ||
Salicin, a bitter-tasting compound, can activate T2R4. This activation may trigger internalization or desensitization of the receptor, reducing its activity and the subsequent signaling events. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $36.00 $55.00 $220.00 $1958.00 | ||
PTU is a thiourea derivative known for its bitter taste and potential to activate T2R4. Activation may induce a feedback mechanism leading to receptor desensitization or internalization, which decreases the functional activity of the receptor. | ||||||
Sucralose | 56038-13-2 | sc-222332 sc-222332A | 100 mg 1 g | $130.00 $454.00 | ||
Sucralose is an artificial sweetener that has been reported to activate T2R4 at high concentrations. This could paradoxically lead to the inhibition of the receptor through a negative feedback loop, causing desensitization or a decrease in receptor expression on the cell surface. | ||||||