T2R06 Inhibitors
T2R06 Inhibitors encompass a variety of bitter-tasting substances that engage this specific G-protein-coupled receptor to inhibit its functional activity, ultimately impeding the perception of bitterness. For instance, Denatonium Benzoate is recognized as an extremely bitter substance that acts as an antagonist to T2R06, obstructing the receptor's ability to be activated by other bitter compounds, which in turn inhibits the signaling cascade that is normally initiated by T2R06 activation. Similarly, Chloroquine and Quinine Hydrochloride are both bitter compounds that bind to T2R06, blocking the receptor and its associated G-protein signaling pathway, which is essential for taste transduction. This blockage results in decreased activation of downstream signaling molecules such as gustducin, phospholipase C, and the subsequent reduction of intracellular calcium release, which are integral to the taste perception process mediated by T2R06.
Moreover, compounds like Propylthiouracil andPhenylthiocarbamide (PTC) also act as T2R06 inhibitors by competitively binding to the receptor, thereby blocking signal transduction cascades involved in the bitter taste sensation. Artificial sweeteners such as Saccharin and Acesulfame Potassium, despite their primary sweet taste, have been found to interact with bitter taste receptors like T2R06, inhibiting the normal bitter signaling pathway and mitigating the cellular responses that lead to bitterness perception. Natural bitter compounds like Naringin, found in grapefruit juice, and Absinthin, from wormwood, also inhibit T2R06 by direct binding, which suppresses signal transduction mechanisms responsible for bitterness sensation. Erythromycin, an antibiotic with inherent bitter qualities, and Aloin, a component of aloe, both function as inhibitors to T2R06 by preventing the initiation of the receptor's signaling cascade. Collectively, these inhibitors act on T2R06 to reduce or prevent the perception of bitterness, highlighting their functional role in the modulation of taste signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $31.00 $46.00 $138.00 $464.00 $903.00 | ||
Denatonium Benzoate is known as one of the most bitter substances and interacts with bitter taste receptors like T2R06. It acts as an antagonist by binding to the receptor, preventing activation by other bitter compounds that would typically trigger a bitter taste sensation, thereby inhibiting the signaling cascade initiated by T2R06. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is also known for its bitter taste and can inhibit T2R06 by binding to the receptor, which prevents the activation of downstream signaling molecules such as gustducin, phospholipase C, and ultimately reduces the intracellular calcium release that would be mediated by T2R06. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $36.00 $55.00 $220.00 $1958.00 | ||
Propylthiouracil has a bitter taste and can inhibit T2R06 by binding to the receptor and blocking its ability to initiate the signal transduction cascade that leads to the perception of bitterness. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Phenylthiocarbamide is known for its ability to interact with certain bitter taste receptors like T2R06. It functions as an inhibitor by binding to the receptor and preventing the normal bitter taste signal transduction that would result in the activation of secondary messengers and the perception of bitterness. | ||||||
Saccharin | 81-07-2 | sc-212902 sc-212902A sc-212902B | 100 mg 1 g 10 g | $173.00 $235.00 $286.00 | ||
Saccharin is a sweetener that also has a bitter aftertaste and can interact with bitter taste receptors such as T2R06. Its binding to T2R06 inhibits the receptor's normal function, thus reducing the bitter taste signaling. | ||||||
Acesulfame Potassium | 55589-62-3 | sc-210736 | 25 g | $240.00 | ||
Acesulfame Potassium is a calorie-free sweetener that can bind to T2R06 and other taste receptors, inhibiting the normal bitter taste signaling pathway and preventing the subsequent cellular responses that would be activated by the receptor. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin with a bitter taste that can inhibit T2R06 by binding to the receptor, thereby hindering the activation of downstream signaling pathways involved in bitter taste perception. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is known for its bitter taste and can act as an antagonist to T2R06 by binding to the receptor, thus preventing the usual G-protein-coupled receptor signaling pathways from activating and leading to the perception of bitterness. | ||||||
Aloin | 1415-73-2 | sc-214525 sc-214525A | 25 mg 100 mg | $156.00 $266.00 | 1 | |
Aloin, a compound found in aloe, possesses a bitter taste and is capable of inhibiting T2R06 by binding to it, which impedes the activation of the taste receptor′s signaling cascade. | ||||||