Syne-1 Activators
The compounds listed above can indirectly modulate the activity of Syne-1 by influencing related cellular structures and signaling pathways. All-trans Retinoic Acid and Staurosporine, for example, can affect gene expression and kinase signaling, respectively, both of which are essential to the functional regulation of Syne-1. Y-27632 and Blebbistatin specifically target components of the cytoskeleton, which is closely linked to Syne-1's role in nuclear positioning and cellular mechanics. Nocodazole and Cytochalasin D disrupt microtubules and actin filaments, respectively, thereby potentially impacting Syne-1's interactions with these cytoskeletal elements. Paclitaxel stabilizes microtubules, providing a contrasting effect that may also influence Syne-1 functions.
Vorinostat and Rapamycin are examples of compounds that modulate chromatin structure and cellular signaling pathways, respectively. These alterations in cellular dynamics can indirectly influence the activity of Syne-1 within the LINC complex. LY294002, as a PI3K inhibitor, impacts signaling pathways that could be relevant to the regulation of Syne-1. Lastly, A23187 and Verapamil, by modulating calcium signaling, can affect a range of cellular processes, including those in which Syne-1 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
As a derivative of Vitamin A, all-trans retinoic acid influences gene expression and nuclear functions, potentially impacting Syne-1 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This potent kinase inhibitor can affect various signaling pathways, potentially having an indirect influence on Syne-1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a specific inhibitor of ROCK (Rho-associated protein kinase), which can modulate cytoskeletal dynamics, indirectly influencing Syne-1-associated functions. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Blebbistatin specifically inhibits myosin II, affecting cytoskeletal organization and potentially impacting Syne-1 functions. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
This agent disrupts microtubule polymerization, potentially affecting Syne-1’s role in nuclear positioning. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin filaments, which can indirectly influence Syne-1’s interaction with the cytoskeleton. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
By stabilizing microtubules, paclitaxel can influence cellular structures and processes involving Syne-1. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor that can alter gene expression and nuclear architecture, potentially impacting Syne-1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, rapamycin affects various cellular signaling pathways and structures, which may be relevant to Syne-1 functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which can modulate signaling pathways relevant to Syne-1. | ||||||