Syne-1 Antibody (3G2): sc-293465

Syne-1 Antibody (3G2) is a mouse monoclonal IgG3 kappa light chain antibody that detects Syne-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Syne-1 antibody (3G2) is available as the non-conjugated format. Syne-1, also known as synaptic nuclear envelope protein-1, plays a crucial role in cellular organization and function, particularly in vesicular trafficking. This 8,797 amino acid protein is a member of the spectrin family, characterized by multiple spectrin repeats, which are essential for maintaining the structural integrity of the Golgi apparatus and nuclear envelope. Notably, Syne-1 is involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum, a process vital for proper distribution of proteins and lipids within the cell. Syne-1′s localization to the Golgi apparatus and nuclear envelope is critical for ensuring cellular components are correctly positioned during cell division. During cytokinesis, Syne-1 migrates to the central spindle and midbody, where Syne-1 collaborates with KIF3B to facilitate accumulation of membrane vesicles, thereby ensuring successful cell division. Syne-1′s ability to interact with various proteins and structural features underscore its importance in maintaining cellular architecture and function, making Syne-1 (3G2) monoclonal antibody an invaluable tool for researchers studying cellular dynamics and trafficking mechanisms.

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Syne-1 Antibody (3G2) References:

1. Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.  |  Apel, ED., et al. 2000. J Biol Chem. 275: 31986-95. PMID: 10878022
2. Golgi localization of Syne-1.  |  Gough, LL., et al. 2003. Mol Biol Cell. 14: 2410-24. PMID: 12808039
3. A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis.  |  Fan, J. and Beck, KA. 2004. J Cell Sci. 117: 619-29. PMID: 14709720
4. The spectrin family member Syne-1 functions in retrograde transport from Golgi to ER.  |  Gough, LL. and Beck, KA. 2004. Biochim Biophys Acta. 1693: 29-36. PMID: 15276322
5. Syne proteins anchor muscle nuclei at the neuromuscular junction.  |  Grady, RM., et al. 2005. Proc Natl Acad Sci U S A. 102: 4359-64. PMID: 15749817
6. Spectrins and the Golgi.  |  Beck, KA. 2005. Biochim Biophys Acta. 1744: 374-82. PMID: 15921768
7. Nesprins: intracellular scaffolds that maintain cell architecture and coordinate cell function?  |  Warren, DT., et al. 2005. Expert Rev Mol Med. 7: 1-15. PMID: 15953398
8. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.  |  Zhang, X., et al. 2007. Development. 134: 901-8. PMID: 17267447
9. Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation.  |  Smith, ER., et al. 2011. Dev Dyn. 240: 2245-55. PMID: 21932307
10. SYNE1 Mutation Is Associated with Increased Tumor Mutation Burden and Immune Cell Infiltration in Ovarian Cancer.  |  Harbin, LM., et al. 2023. Int J Mol Sci. 24: PMID: 37762518
11. Exome sequencing implicates ancestry-related Mendelian variation at SYNE1 in childhood-onset essential hypertension.  |  Copeland, I., et al. 2024. JCI Insight. 9: PMID: 38716726
12. Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.  |  Zhang, Q., et al. 2001. J Cell Sci. 114: 4485-98. PMID: 11792814