Su Inhibitors
Su inhibitors predominantly target enzymes involved in folate metabolism, particularly dihydrofolate reductase (DHFR), thymidylate synthase, and other folate-dependent enzymes essential for nucleotide synthesis. By blocking these enzymes, Su inhibitors disrupt the production of essential nucleotides required for DNA synthesis, leading to inhibition of cell proliferation and growth. These inhibitors are effective agents against cancer and certain infectious diseases.
Su inhibitors comprise a diverse class of compounds that target enzymes involved in folate metabolism, particularly dihydrofolate reductase (DHFR) and thymidylate synthase. By inhibiting these key enzymes, Su inhibitors disrupt the synthesis of essential nucleotides required for DNA replication and cell proliferation. This disruption in nucleotide synthesis leads to cytotoxic effects. Additionally, Su inhibitors exhibit selectivity towards rapidly dividing cells, further enhancing their efficacy against proliferative disorders.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase (DHFR), an enzyme involved in folate metabolism, thereby disrupting nucleotide synthesis. | ||||||
Aminopterin | 54-62-6 | sc-202461 | 50 mg | $102.00 | 1 | |
Aminopterin inhibits dihydrofolate reductase (DHFR), blocking the conversion of dihydrofolate to tetrahydrofolate, crucial for DNA synthesis. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
Pyrimethamine inhibits dihydrofolate reductase (DHFR), disrupting the synthesis of tetrahydrofolate and inhibiting DNA synthesis in parasites. | ||||||
Pemetrexed Disodium | 150399-23-8 | sc-219564 | 10 mg | $133.00 | 5 | |
Pemetrexed inhibits multiple folate-dependent enzymes, including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, disrupting nucleotide synthesis. | ||||||
Folotyn | 146464-95-1 | sc-364491 sc-364491A | 10 mg 50 mg | $480.00 $1455.00 | ||
Pralatrexate is a folate analog that competitively inhibits dihydrofolate reductase (DHFR), blocking the conversion of dihydrofolate to tetrahydrofolate and inhibiting DNA synthesis. | ||||||
Raltitrexed | 112887-68-0 | sc-219933 | 10 mg | $143.00 | ||
Raltitrexed is a thymidylate synthase inhibitor that blocks the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), inhibiting DNA synthesis. | ||||||
Tegafur | 17902-23-7 | sc-205855 sc-205855A | 250 mg 1 g | $115.00 $232.00 | ||
Tegafur is a prodrug of 5-fluorouracil (5-FU), which inhibits thymidylate synthase, disrupting DNA synthesis and exerting cytotoxic effects. | ||||||