SRRD Activators

These selected chemicals act on various pathways and biological processes such as sirtuin activation, AMPK pathways, PI3K/Akt signaling, MET signaling, Wnt signaling, transcriptional regulation through histone deacetylation, PPARδ activation, estrogen receptor modulation, retinoic acid signaling, CREB activation, and NF-kB activation. All of these pathways can have downstream effects on the cellular processes that are involving SRRD.

SRRD activators comprise compounds that modulate diverse cellular signaling pathways and transcriptional programs. These activators do not directly bind or modify SRRD but function upstream in cellular processes that are anticipated to involve the RNA processing roles of SRRD. For example, Resveratrol and AICAR function by enhancing sirtuin pathways and AMPK activation, respectively, both of which are associated with metabolic regulation and could affect RNA processing mechanisms. Through these processes, cellular conditions conducive to increased RNA biogenesis and processing could be created, indirectly involving SRRD's role in these cellular functions. Similarly, PI3K/Akt pathway activation through agents like 740 Y-P can result in a cascade of events promoting transcription and translation, processes that are intimately linked with RNA processing activities where SRRD is implicated. Continuing with this theme, Wnt signaling pathway activators, histone deacetylase activators, and transcription factor modulators such as NF-kB activators can initiate a series of transcriptional changes. These alterations in gene expression profiles are likely to have ripple effects on RNA processing and biogenesis. The modulation of these pathways through selected compounds like BIO, ITSA-1, and Prostratin, therefore, could lead to enhanced RNA biogenesis and processing. Estrogen receptor modulators and retinoic acid signaling molecules like Diethylstilbestrol and Retinoic Acid, known to impact gene expression, might also play a role in fine-tuning the cellular processes involving SRRD.