SRPX Activators
SRPX Activators are a diverse collection of chemical compounds that bolster the functional activity of SRPX through various interconnected cellular processes, primarily related to cell migration, adhesion, and angiogenesis. The activation of SRPX by Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF) occurs via the stimulation of their respective receptor tyrosine kinases, leading to signaling cascades that underlie cellular proliferation and motility, processes in which SRPX is fundamentally involved. Sphingosine-1-phosphate (S1P) and Lysophosphatidic acid (LPASRPX Activators encompass a range of chemical compounds that indirectly enhance the functional activity of SRPX by interfacing with biochemical pathways integral to cell adhesion, migration, and angiogenesis. Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), by engaging their respective receptor tyrosine kinases, initiate signaling cascades that culminate in cell proliferation and migration, a domain where SRPX is known to play a role. On a similar note, Vascular Endothelial Growth Factor (VEGF) specifically promotes angiogenesis, a process where SRPX's role has been implicated, potentially boosting SRPX function in vascular development. Phorbol 12-myristate 13-acetate (PMA) acts as a potent activator of Protein Kinase C (PKC), which is involved in a multitude of cellular functions including the modulation of cell adhesion and migration, thereby indirectly influencing SRPX activity by reinforcing the cellular pathways that SRPX is a part of. Fibronectin and collagen, as major constituents of the extracellular matrix, can modulate cell-matrix interactions, indirectly enhancing SRPX function in cell adhesion and migration through integrin-mediated signaling pathways.
Furthermore, Sphingosine-1-phosphate (S1P) exerts its effects by binding to its specific G-protein-coupled receptors, influencing cell migration and angiogenesis, which could lead to an enhanced functional activity of SRPX by promoting the cellular pathways related to its function. Similarly, Lysophosphatidic acid (LPA) and Arg-Gly-Asp (RGD) peptides, by interacting with their respective receptors and integrins, can facilitate cell migration and adhesion, indirectly augmenting SRPX's involvement in these processes. The Focal Adhesion Kinase (FAK) activator and integrin activator compounds further support this enhancement of SRPX activity by strengthening cell adhesion and migration pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P acts on its receptors to influence cell migration and angiogenesis. SRPX, being implicated in similar processes, could have its functional activity enhanced as S1P signaling promotes cellular pathways relevant to SRPX functions. | ||||||
FAK Inhibitor 14 | 4506-66-5 | sc-203950 sc-203950A | 10 mg 50 mg | $107.00 $233.00 | 86 | |
A FAK activator would promote cell adhesion and migration pathways. Since SRPX is involved in cell adhesion, enhancing FAK activity could indirectly augment SRPX's role in these processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that can enhance cell adhesion and migration. By activating PKC, PMA could potentially increase SRPX activity indirectly by stimulating the pathways in which SRPX is involved. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA is involved in cell migration and survival, and by engaging its receptors, it could enhance SRPX activity indirectly by influencing these cellular pathways. | ||||||
Fibronectin | sc-29011 sc-29011A | 1 mg 5 mg | $140.00 $494.00 | 94 | ||
Fibronectin promotes cell adhesion and migration, and SRPX is known to be expressed in regions where these processes are vital. The presence of fibronectin could thus bolster SRPX activity indirectly. | ||||||
Collagen IV | sc-29010 | 1 mg | $220.00 | 11 | ||
Collagen is a major component of the extracellular matrix and can influence cell adhesion and migration. By engaging with integrins and other receptors, collagen could indirectly augment SRPX activity. | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $204.00 | ||
Hyaluronic acid is involved in cell proliferation and migration. It could indirectly enhance SRPX activity by influencing the extracellular matrix and cellular pathways SRPX is involved in. | ||||||