Molecular structure of FAK Inhibitor 14, CAS Number: 4506-66-5
FAK Inhibitor 14 (CAS 4506-66-5)
See product citations (86)
Alternate Names:
1,2,4,5-tetraaminobenzene tetra hydrochloride
Application:
FAK Inhibitor 14 is a potent FAK inhibitor that demonstrates antiproliferative activity in several tumor cell lines
CAS Number:
4506-66-5
Purity:
≥90%
Molecular Weight:
284.01
Molecular Formula:
C6H10N4•4HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FAK Inhibitor 14 is a selective FAK (focal adhesion kinase) inhibitor that displays no significant activity for a range of other kinases including PDGFR, EGFR, and IGF-RI. FAK Inhibitor 14 may act to prevent FAK autophosphorylation at the putative activation site, tyrosine 397 (IC50 of 1muM). FAK Inhibitor 14 may act to promote cell detachment and inhibit cell adhesion in vitro, and to exhibit antiproliferative activity in a variety of human tumor cell lines in vivo such as: breast cancer cell lines BT474 and MCF-7, pancreatic cancer cell lines Panc-1 and Miapaca-2, and neuroblastoma cell lines MYCN+/MYCN- (with a greater effect on the negative isogenic form). FAK Inhibitor 14 has also been used to study the conformation and self replication methodology of bis capped porphyrins.
FAK Inhibitor 14 (CAS 4506-66-5) References
- NQ-Y15 inhibits the calcium mobilization by elevation of cyclic AMP in rat platelets. | Chang, TS., et al. 2001. Biol Pharm Bull. 24: 480-3. PMID: 11379764
- The synthesis and studies towards the self-replication of bis(capped porphyrins). | Thordarson, P., et al. 2003. Org Biomol Chem. 1: 1216-25. PMID: 12926398
- Distinct functions of Cdk5(Y15) phosphorylation and Cdk5 activity in stress fiber formation and organization. | Qiao, F., et al. 2008. Exp Cell Res. 314: 3542-50. PMID: 18838073
- A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. | Golubovskaya, VM., et al. 2008. J Med Chem. 51: 7405-16. PMID: 18989950
- A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. | Hochwald, SN., et al. 2009. Cell Cycle. 8: 2435-43. PMID: 19571674
- Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. | Beierle, EA., et al. 2010. Cell Cycle. 9: 1005-15. PMID: 20160475
- Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. | Golubovskaya, VM., et al. 2013. Mol Cancer Ther. 12: 162-72. PMID: 23243059
- The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide. | Huang, G., et al. 2014. Anticancer Agents Med Chem. 14: 9-17. PMID: 23387973
- Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. | Heffler, M., et al. 2013. Cancer Biol Ther. 14: 761-72. PMID: 23792569
- FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. | O'Brien, S., et al. 2014. Oncotarget. 5: 7945-59. PMID: 25277206
- Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15. | Golubovskaya, V., et al. 2015. J Cancer Res Clin Oncol. 141: 1613-31. PMID: 25656374
- Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. | Caspari, T. and Hilditch, V. 2015. PLoS One. 10: e0130748. PMID: 26131711
- Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways. | Zhang, H., et al. 2016. Br J Cancer. 115: 203-11. PMID: 27336608
- Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets. | Chang, TS., et al. 1997. Biochem Pharmacol. 54: 259-68. PMID: 9271330
Inhibitor of:
Angiomotin-L2, AVL9, EG210155, FAK, ITFG2, Pinch-1, and Tyrosine Kinase.Activator of:
BRDG1, FNBP2, Kindlin-3, SRPX, and Talin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAK Inhibitor 14, 10 mg | sc-203950 | 10 mg | $109.00 | |||
FAK Inhibitor 14, 50 mg | sc-203950A | 50 mg | $238.00 |