SPT4 Activators
SPT4 activators are a group of chemicals that modulate the activity of SPT4, a protein that forms part of the Spt4/Spt5 complex, also known as the DSIF complex in eukaryotes, which is involved in the regulation of transcription elongation. The function of SPT4 within this complex is crucial for the proper elongation phase of transcription by RNA polymerase II, where it acts to prevent pausing of the polymerase on the DNA template. Activators of SPT4 can either exert their effects directly, by binding to the protein and inducing a conformational change that enhances its interaction with RNA polymerase II and Spt5, or they can act indirectly, by modulating the expression levels of SPT4 or the post-translational modifications that affect its function..
Direct activators interact with specific domains of SPT4, stabilizing the Spt4/Spt5 complex in a formation that promotes its processivity function. This could involve the enhancement of the affinity between SPT4 and the RNA polymerase II or facilitating the recruitment of additional factors that aid in the progression of the polymerase along the DNA. Such compounds might also mimic naturally occurring ligands or substrates of the Spt4/Spt5 complex, fostering tighter binding and more efficient transcription elongation. Indirect activators influence the cellular signaling pathways that control the transcription or translation of the SPT4 gene, thereby increasing the production of SPT4 protein. They can also affect the stability of SPT4 by inhibiting pathways that lead to its degradation or by modifying its interactions with other proteins that regulate its turnover. Additionally, the modulation of other factors within the transcription machinery that interact with SPT4 can ndirectly result in the enhanced activity of SPT4.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a small molecule that inhibits the bromodomain-containing protein 4 (BRD4). BRD4 is known to regulate transcription elongation, a process in which SPT4 is involved. Therefore, JQ1 can indirectly affect SPT4 by altering the transcription elongation landscape. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid is a pentacyclic triterpenoid that has been shown to inhibit HIV-1 transcription. As SPT4 is involved in transcription elongation, its activity can be indirectly influenced by Betulinic Acid. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D is a DNA intercalator that inhibits transcription, thereby potentially influencing the transcription elongation process in which SPT4 is involved. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a cyclic peptide that inhibits RNA polymerase II, the enzyme responsible for mRNA synthesis during transcription. As SPT4 is a component of the elongation complex of RNA polymerase II, it can be indirectly affected by α-Amanitin. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol is a cyclin-dependent kinase (CDK) inhibitor. CDKs are involved in regulating transcription and could indirectly influence SPT4, which is part of the transcription elongation machinery. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is an inhibitor of RNA polymerase II CTD phosphorylation and can indirectly affect SPT4, which is part of the RNA polymerase II transcription elongation complex. | ||||||