sPLA2 Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY315920 | 172732-68-2 | sc-364528 sc-364528A | 5 mg 10 mg | $315.00 $490.00 | ||
LY315920 acts as a selective sPLA2 inhibitor, engaging with the enzyme through specific hydrophobic and electrostatic interactions that stabilize its binding. This compound alters the hydrolysis of phospholipids, impacting lipid metabolism and inflammatory pathways. Its unique kinetic properties reveal a non-competitive inhibition mechanism, leading to a distinct modulation of arachidonic acid release. The compound's structural characteristics promote unique conformational dynamics within the enzyme, influencing its overall activity. | ||||||
Oleyloxyethyl Phosphorylcholine | 96720-06-8 | sc-200711 sc-200711A | 10 mg 50 mg | $80.00 $283.00 | 6 | |
Oleyloxyethyl Phosphorylcholine exhibits a distinctive role as a sPLA2 modulator, characterized by its ability to form strong hydrogen bonds and hydrophobic interactions with the enzyme's active site. This compound influences the enzymatic hydrolysis of phospholipids, thereby affecting membrane integrity and signaling pathways. Its reaction kinetics suggest a unique allosteric modulation, altering substrate affinity and enzymatic turnover rates, which can lead to significant changes in lipid-derived signaling molecules. | ||||||
7,7-Dimethyleicosadienoic Acid (DEDA) | 89560-01-0 | sc-200707 sc-200707A | 10 mg 50 mg | $99.00 $364.00 | ||
7,7-Dimethyleicosadienoic Acid (DEDA) acts as a potent sPLA2 modulator, showcasing unique interactions with the enzyme's catalytic site. Its structural features facilitate specific van der Waals forces and electrostatic interactions, enhancing substrate binding efficiency. DEDA's influence on lipid metabolism is evident through its ability to alter reaction kinetics, promoting distinct pathways in phospholipid turnover and impacting downstream signaling cascades. This compound's behavior underscores its role in lipid dynamics and cellular responses. | ||||||
Luffariellolide | 111149-87-2 | sc-202212 | 1 mg | $263.00 | ||
Luffariellolide exhibits remarkable specificity as an sPLA2 inhibitor, engaging in unique hydrogen bonding and hydrophobic interactions with the enzyme's active site. Its structural conformation allows for selective modulation of phospholipid hydrolysis, influencing the kinetics of substrate turnover. This compound also alters membrane fluidity, which can affect enzyme accessibility and activity, thereby shaping lipid signaling pathways and cellular membrane dynamics in a distinctive manner. | ||||||
Thioetheramide PC | 116457-99-9 | sc-202840 sc-202840A | 5 mg 25 mg | $64.00 $321.00 | ||
Thioetheramide PC acts as a potent sPLA2 modulator, characterized by its ability to form stable complexes with the enzyme through unique electrostatic interactions. Its distinct molecular architecture facilitates selective binding, influencing the catalytic efficiency and substrate affinity. Additionally, Thioetheramide PC can alter lipid bilayer properties, impacting membrane permeability and fluidity, which may lead to significant changes in cellular signaling and lipid metabolism pathways. | ||||||
4-[(1-oxo-7-phenylheptyl)amino]-(4R)-octanoic acid | 1101136-50-8 | sc-223602 sc-223602A | 1 mg 5 mg | $39.00 $231.00 | ||
4-[(1-oxo-7-phenylheptyl)amino]-(4R)-octanoic acid exhibits unique interactions with sPLA2, enhancing its enzymatic activity through specific hydrophobic and hydrogen bonding interactions. This compound's structural features allow it to modulate the enzyme's conformation, potentially affecting substrate access and turnover rates. Furthermore, it influences lipid dynamics within membranes, which may alter the local microenvironment and impact downstream signaling cascades. | ||||||