Molecular structure of LY315920, CAS Number: 172732-68-2
LY315920 (CAS 172732-68-2)
Alternate Names:
Varespladib
Application:
LY315920 is a potent and selective sPLA2 (secretory phospholipase A2) inhibitor
CAS Number:
172732-68-2
Purity:
≥98%
Molecular Weight:
380.39
Molecular Formula:
C21H20N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY315920 is a compound of interest within the field of enzyme inhibition. It is used as a selective inhibitor of secretory phospholipase A2 (sPLA2), an enzyme that plays a role in the release of arachidonic acid and subsequent production of eicosanoids. By studying the inhibitory effects of LY315920, insights into the modulation of inflammatory responses where sPLA2 is implicated. The compound also can probe the structure-activity relationships of sPLA2, aiding in the understanding of how the enzyme′s conformation affects its interaction with inhibitors. LY315920 is utilized in biochemical assays to investigate the involvement of sPLA2 in various cellular processes. Studies involving LY315920 contributes to the broader comprehension of enzyme regulation and the mechanisms of inflammation at the molecular level.
LY315920 (CAS 172732-68-2) References
- Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. | Snyder, DW., et al. 1999. J Pharmacol Exp Ther. 288: 1117-24. PMID: 10027849
- Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. | Oslund, RC., et al. 2008. J Med Chem. 51: 4708-14. PMID: 18605714
- Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. | Dennis, EA., et al. 2011. Chem Rev. 111: 6130-85. PMID: 21910409
- sPLA2-IIA Augments Oxidized LDL-Induced MCP-1 Expression in Vitro Through Activation of Akt. | Guo, Y., et al. 2015. Cell Physiol Biochem. 37: 1345-54. PMID: 26488172
- Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. | Lewin, M., et al. 2016. Toxins (Basel). 8: PMID: 27571102
- Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2. | Bryan-Quirós, W., et al. 2019. Toxicon. 157: 1-7. PMID: 30447275
- Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib). | Bittenbinder, MA., et al. 2018. Toxins (Basel). 10: PMID: 30518149
- Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920). | Salvador, GHM., et al. 2019. Sci Rep. 9: 17203. PMID: 31748642
- Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms. | Gutiérrez, JM., et al. 2020. Toxins (Basel). 12: PMID: 32093386
- Varespladib (LY315920) neutralises phospholipase A2 mediated prothrombinase-inhibition induced by Bitis snake venoms. | Youngman, NJ., et al. 2020. Comp Biochem Physiol C Toxicol Pharmacol. 236: 108818. PMID: 32512199
- Varespladib (LY315920) inhibits neuromuscular blockade induced by Oxyuranus scutellatus venom in a nerve-muscle preparation. | Fontana Oliveira, IC., et al. 2020. Toxicon. 187: 101-104. PMID: 32889027
- Anticoagulant Micrurus venoms: Targets and neutralization. | Dashevsky, D., et al. 2021. Toxicol Lett. 337: 91-97. PMID: 33197555
- Clinical management of snakebite envenoming: Future perspectives. | Hamza, M., et al. 2021. Toxicon X. 11: 100079. PMID: 34430847
- Varespladib (LY315920) prevents neuromuscular blockage and myotoxicity induced by crotoxin on mouse neuromuscular preparations. | Maciel, FV., et al. 2021. Toxicon. 202: 40-45. PMID: 34562493
- Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model. | Tan, CH., et al. 2022. Acta Trop. 227: 106289. PMID: 34929179
Inhibitor of:
group II sPLA2, sPLA2, and TRPV3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY315920, 5 mg | sc-364528 | 5 mg | $315.00 | |||
LY315920, 10 mg | sc-364528A | 10 mg | $490.00 |